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Product Details

17-PAAG | Propargyl geldanamycin

17-PAAG is a semi-synthetic analog of geldanamycin which possesses an acetylenic side chain for coupling to other probes, fluorophores and bioactive molecules such as steroids via click chemistry.1 Chemical modifications at C17 are well known not to interfere with binding of geldanamycin to HSP90 client proteins.2-4

References/Citations

1) Hendricks et al. (2013), Synthesis and preliminary evaluation steroidal anti-estrogen-geldanamycin conjugates; Bioorg. Med. Chem. Lett., 23 3635
2) Llauger-Bufi et al. (2003), Synthesis of novel fluorescent probes for the molecular chaperone Hsp90; Bioorg. Med. Chem. Lett., 13 3975
3) Kim et al. (2004), Development of a fluorescence polarization assay for the molecular chaperone Hsp90; J. Biomol. Screen., 9 375
4) Austin et al. (2012), Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors; J. Biomol. Screen, 17 868

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Catalog#  10-1601-0002

$55.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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Catalog Number:
10-1601
Activity:
Propargyl geldanamysin
Chemical Name:
17-(Propargylamino)-17-desmethoxygeldanamycin
Molecular Weight:
538.67
Molecular Formula:
C31H41N3O8
Solubility:
Soluble in DMSO (up to at least 50 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
Violet solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
FeaturedDescription:
Semi-synthetic analog of geldanamycin which possesses an acetylenic side chain for coupling to other probes, fluorophores and bioactive molecules such as steroids via click chemistry.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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