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Product Details

24(S),25-Epoxycholesterol | LXR agonist

24(S),25-Epoxycholesterol (77058-74-3) is a cholesterol metabolite that acts as an endogenous agonist for nuclear receptor LXR.1 Controls cellular cholesterol homeostasis.2 24(S),25-Epoxycholesterol promotes neural development in zebra fish as well as dopaminergic differentiation of embryonic stem cells.3 Cell permeable.

References/Citations
1) Chawla et al. (2001), Nuclear receptors and lipid physiology: opening the X-files; Science, 294 1866
2) Brown et al. (2009), 24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis; Int. J. Biochem. Cell Biol., 41 744
3) Theofilopoulos et al. (2013), Brain endogenous liver X receptor igands selectively promote midbrain neurogenesis; Nature Chem. Biol., 9 126

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24(S),25-Epoxycholesterol | 77058-74-3 | Structure | Supplier

Catalog#  10-1330

$150.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
77058-74-3
Catalog Number:
10-1330
Activity:
LXR agonist
Molecular Weight:
400.65
Molecular Formula:
C27H44O2
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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