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Product Details

6BIO | GSK-3 inhibitor

6BIO (667463-62-9) is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM.1 The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells.2 Promotes proliferation in mammalian cardiomyocytes.2 6BIO is a potent inhibitor of malignant lymphoid cell proliferation.3

References/Citations
1) Meijer et al. (2003), GSK-3-selective inhibitors derived from Tyrian purple indirubins; Chem. Biol., 10 1255
2) Tseng et al. (2006), The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes; Chem. Biol., 13 957
3) Chebel et al. (2009), Indirubin derivatives inhibit malignant lymphoid cell proliferation; Leuk. Lymphoma, 50 2049

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6BIO | 667463-62-9 | Structure | Supplier

Catalog#  10-1400

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
667463-62-9
Catalog Number:
10-1400
Activity:
GSK-3 inhibitor
Chemical Name:
(2'Z,3'E)-6-Bromoindirubin-3'oxime
Molecular Weight:
356.18
Molecular Formula:
C16H10BrN3O2
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 4 mg/ml with warming).
Physical Properties:
Purple solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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