my account
Login
  Loading... Please wait...

Product Details

AdipoRon | Adiponectin agonist

AdipoRon (924416-43-3) is a novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively1. Displayed similar effects to adiponectin in muscle and liver such as activation of PPARα and AMPK signaling pathways. It also reversed insulin resistance and glucose intolerance in mice on a high-fat diet. AdipoRon ameliorated diabetes in a genetically obese mouse model and prolonged the shortened lifespan of db/db mice on a high-fat diet1.  Attenuates PDGF-induced VSMC proliferation via inhibition of mTPR signaling in an AMPK independent manner.2 Active in vivo.

References/Citations
1) Okada-Iwabu et al. (2013), A small-molecule AdipoR agonist for type 2 diabetes and short life obesity; Nature, 503 493
2) Fairaq et al. (2017), AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: Implications toward suppression of neointimal hyperplasia; Pharmacol. Res. 119 289

swipe
AdipoRon | 924416-43-3 | Structure | Supplier

Catalog#  10-1483

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
924416-43-3
Catalog Number:
10-1483
Activity:
Adiponection agonist
Chemical Name:
2-(4-Benzylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
Molecular Weight:
428.54
Molecular Formula:
C27H28N2O3
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the AdipoRon | Adiponectin agonist to your wish list.