Modify Search
Select all
Products
Pages
Posts
Modify Search
Select all
Products
Pages
Posts

AGI-5198 | R132 mutant isocitrate dehydrogenase inhibitor

CAS:
1355326-35-0
Catalog Number:
10-4599
Activity:
R132 mutant isocitrate dehydrogenase inhibitor
Chemical Name:
N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide
Molecular Weight:
462.56
Molecular Formula:
C27H31FN4O2
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

AGI-5198 (135526-35-0) is a potent (IC50 = 70 nM) inhibitor of mutant isocitrate dehydrogenase 1(IDH1).1  It is selective for the R132H-IDH1 mutant and does not affect wild type cells.2  This mutation results in loss-of-function for oxidative decarboxylation of isocitrate and gain-of-function for production of the oncometabolite R-2-hydroxyglutarate (R-2HG) from alpha-ketoglutarate (2-OG).

References/Citations:

1) Popovici-Muller et al. (2012), Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG In Vivo; ACS Med. Chem. Lett., 3 850
2) Rohle et al. (2013), An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells; Science, 340 626

AGI-5198 | R132 mutant isocitrate dehydrogenase inhibitor is also available in the Cellular Metabolism Library.
CAS:
1355326-35-0
Catalog Number:
10-4599
Activity:
R132 mutant isocitrate dehydrogenase inhibitor
Chemical Name:
N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide
Molecular Weight:
462.56
Molecular Formula:
C27H31FN4O2
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Add to Quote

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee