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Product Details

AICAR | AMPK activator

AICAR (2627-69-2) activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor. Promotes skeletal muscle autophagy via activation of FoxO3a. AICAR controls smooth muscle cell hyperproliferation in vascular disease. Cell permeable.

References/Citations
1) Chopra et al. (2012), Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle; Diabetologia, 55 783
2) Sanchez et al. (2012), AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1; J. Cell Biochem., 113 695
3) Ferri et al. (2012), AMP-activated protein kinase and the control of smooth muscle cell hyperproliferation in vascular disease; Vascul. Pharmacol., 56 9

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AICAR | 2627-69-2 | Structure | Supplier

Catalog#  10-1092-0050

$40.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
2627-69-2
Catalog Number:
10-1092
Activity:
AMPK activator
Alternate Names:
Acadesine
Chemical Name:
5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside
Molecular Weight:
258.24
Molecular Formula:
CH14N4O5
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Water (up to 15 mg/ml).
Physical Properties:
Off-white solid
Purity:
>99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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