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PhysioProcesses

Angiogenesis

Angiogenesis is the formation of new blood vessels from existing vasculature involving migration, growth, and differentiation of endothelial cells. It requires growth factors (e.g. VEGF, TGF-β), Notch, PI3K, proteases, adhesion molecules, and other signaling components that control cell growth, differentiation, and migration. Angiogenesis occurs in normal processes such as wound healing and embryonic development, but it also plays key roles in pathologies such as cancer and inflammation.

Cytokines

Growth factors

Vandetanib | VEGFR2 inhibitor

CAS:
443913-73-3
Catalog Number:
10-2185
Activity:
VEGFR2 inhibitor
Chemical Names:
4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-yl)methoxy]quinazoline
Alternate Name:
ZD6474
Molecular Weight:
475.35
Molecular Formula:
C22H24BrFN4O2
Solubility:
Soluble in DMSO (30 mg/ml); Ethanol (10 mg/ml with warming)
Physical Properties:
White to off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Lenvatinib | VEGFR inhibitor

CAS:
417716-92-8
Catalog Number:
10-3313
Activity:
VEGFR inhibitor
Chemical Name:
4-[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide
Alternate Names:
E7080
Molecular Weight:
426.85
Molecular Formula:
C21H19ClN4O4
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

HIF

Herboxidiene | Spliceosome inhibitor

CAS:
142861-00-5
Catalog Number:
10-1614
Activity:
Spliceosome inhibitor
Alternate Names:
GEX1A
Molecular Weight:
438.60
Molecular Formula:
C25H42O6
Solubility:
Soluble in DMSO or Ethanol
Physical Properties:
White solid
Purity:
97% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

MetAP2

Fumagillin | MetAP-2 inhibitor

CAS:
23110-15-8
Catalog Number:
10-1146
Activity:
MetAP-2 inhibitor
Chemical Name:
(2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester
Molecular Weight:
458.54
Molecular Formula:
C26H34>/sub>O7
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Orange solid
Purity:
95% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

MMPs

PNF1 | Angiogenesis inducer

CAS:
10442-95-2
Catalog Number:
10-5556
Activity:
Angiogenesis inducer
Chemical Names:
2-(2-Oxocyclopentyl)isoindoline-1,3-dione; SC-3-149
Molecular Weight:
229.24
Molecular Formula:
C13H11NO3
Solubility:
Soluble in DMSO (35 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

YAP/TAZ

Verteporfen | YAP Inhibitor

CAS:
129497-78-5
Catalog Number:
10-3487
Activity:
YAP inhibitor
Chemical Name:

(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

Alternate Names:
CL 318952; BPD-MA
Molecular Weight:
718.79
Molecular Formula:
C41H42N4O8
Solubility:
Soluble in DMSO (up to 14 mg/ml)
Physical Properties:
Black solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchsae as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Other Angiogenesis

Halofuginone HBr | Prolyl-tRNA synthetase inhibitor

Halofuginone (64924-67-0) is a potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and

FAK inhibitor 14 | FAK inhibitor

CAS:
4506-66-5
Catalog Number:
10-2547
Activity:
FAK inhibitor
Alternate Names:
Y15
Chemical Name:
1,2,4,5-Benzenetetramine tetrahydrochloride
Molecular Weight:
284.02
Molecular Formula:
C6H10N4 4HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 15 mg/ml).
Physical Properties:
Grey solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT