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Argatroban | Thrombin inhibitor

CAS:
74863-84-6
Catalog Number:
10-2809
Activity:
Thrombin inhibitor
Alternate Names:
Argidipine; MQPA
Chemical Name:
(2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
Molecular Weight:
508.63
Molecular Formula:
C23H36N6O5S
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Argatroban (74863-84-6) is a potent and selective inhibitor of thrombin (Ki = 19 nM).1 Prevents platelet-rich arterial thrombosis in a rabbit model.2 Ameliorates early brain injury and improves neurological outcomes after subarachnoid hemorrhage in a rat model.3 Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and independent mechanisms.4

References/Citations:

1) Kikumoto et al. (1984), Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-l-arginyl)]-2-piperidinecarboxylic acid; Biochemistry, 23 85
2) Jang et al. (1990), Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition; Circulation, 81 219
3) Sugawara et al. (2009), Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats; Stroke, 40 1530
4) Schulze et al. (2008), The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms; Breast Cancer Res. Treat., 112 243

Argatroban | Thrombin inhibitor is also available in the Cellular Metabolism Library.
CAS:
74863-84-6
Catalog Number:
10-2809
Activity:
Thrombin inhibitor
Alternate Names:
Argidipine; MQPA
Chemical Name:
(2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
Molecular Weight:
508.63
Molecular Formula:
C23H36N6O5S
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

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