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AS-8351 | KDM5B histone demethylase inhibitor

CAS:
796-42-9
Catalog Number:
10-1597
Activity:
KDM5B histone demethylase inhibitor
Chemical Names:
2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
Molecular Weight:
291.30
Molecular Formula:
C17H13N3O2
Solubility:
Soluble in DMSO (45 mg/ml); ethanol (10 mg/ml with warming)
Physical Properties:
Yellow solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

AS-8351 (796-42-9) has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts.1 It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.1

References/Citations:

1) Cao et al. (2016), Conversion of human fibroblasts into functional cardiomyocytes by small molecules; Science, 352 1216

AS-8351 | KDM5B histone demethylase inhibitor is also available in the Cellular Metabolism Library.
CAS:
796-42-9
Catalog Number:
10-1597
Activity:
KDM5B histone demethylase inhibitor
Chemical Names:
2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
Molecular Weight:
291.30
Molecular Formula:
C17H13N3O2
Solubility:
Soluble in DMSO (45 mg/ml); ethanol (10 mg/ml with warming)
Physical Properties:
Yellow solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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