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Inhibitors

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  • 3-Methyladenine | Autophagosome inhibitor
    $44.00
    3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and...

  • Antipain 2HCl | Serine and cysteine protease inhibitor
    $35.00
    Serine/cysteine protease inhibitor. Also inhibits some trypsin-like proteases.1 May be used as an additive to prevent proteolytic activity during recombinant protein production in Sf-9 insect cell cultures.2 May be employed...

  • Bafilomycin A1 | Vacuolar H+ ATPase inhibitor
    $80.00
    Bafilomycin A1 (88899-55-2) is a macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 – 1.5 nM).1,2 Bafilomycin A1 inhibits autophagy via...

  • Chloroquine phosphate | autophagy inhibitor
    $25.00
    Chloroquine phosphate (50-63-5) is an antimalarial drug. Inhibits autophagy in a variety of cell lines1. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of...

  • DBeQ | 177355-84-9 | Structure | Supplier
    $65.00
    DBeQ (177355-84-9) is a potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks ubiquitin-dependent protein clearance pathways. Cell...

  • Hydroxychloroquine sulfate | 747-36-4 | Structure | Supplier
    $60.00
    Hydrochloroquine sulfate (747-36-4) is a lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types.1,2 Augments the anticancer activity of DNA-damaging chemotherapy...

  • ISO-1 | 478336-92-4 | Structure | Supplier
    $105.00
    ISO-1 (478336-92-4) is an antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis1. Inhibits airway remodeling in...

  • Leonurine | Neuroinflammation inhibitor
    $48.00
    Inhibits microglial overactivation and attenuates Aβ(1-40)-induced cognitive impairments in rats via JNK and NF-κB pathways.1 Inhibits the formation of advanced glycation end products.2 Ameliorates cognitive...

  • Manzamine A | Inhibitor of vacuolar ATPases
    $185.00
    Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis in vivo2. Manzamine A displays neuritogenic activity3 and suppresses tau...

  • MHY1485 | mTOR activator
    $44.00
    MHY1485 (326914-06-1) is an mTOR activator. Suppresses autophagy by inhibiting the fusion of autophagosomes with lysosomes leading to the accumulation of enlarged autophagosomes.1 Increases ovarian follicle development.2...

  • SBI-0206965 | ULK1 inhibitor
    $65.00
    SBI-0206965 (1884220-36-3) is a potent and selective inhibitor of the autophagy kinase ULK-1, IC50=108 and 711 nM for ULK1 and 2 respectively.1 Suppresses autophagy induced by mTOR inhibitors and thus synergizes with mTOR...

  • Spautin-1 | 1262888-28-7 | Structure | Supplier
    $70.00
    Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1...

  • Vinblastine sulfate | Microtubule depolymerizer
    $48.00
    Vinblastine sulfate (143-67-9) is a semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation.1 Inhibits normal microtubule assembly and induces aberrant...

  • Wortmannin | PI3K inhibitor
    $40.00
    Wortmannin (19545-26-7) is a potent and selective inhibitor of PI3-kinase which acts via covalent modification of Lys-802.2 Inhibits autophagy in rat hepatocytes.3 Inhibits adipocyte differentiation of 3T3-L1 cells...

  • Xanthohumol | 6754-58-1 | Structure | Supplier
    $140.00
    Xanthohumol (6754-58-1) binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome...

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