my account
Login
  Loading... Please wait...

Product Details

BAY 11-7082 | IKK inhibitor

BAY 11-7082 (19542-67-7) selectively inhibits TNFα-induced phosphorylation of IκB-α leading to decreased nuclear NF-κB and decreased adhesion molecule expression without affecting constitutive IκB-α phosphorylation.1 The effects on adhesion molecule expression were found to be irreversible.

References/Citations
1) Pierce et al. (1997) Novel inhibitor of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J. Biol. Chem. 272 21096

swipe
BAY 11-7082 | 19542-67-7 | Structure | Supplier

Catalog#  10-1296

$70.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
19542-67-7
Catalog Number:
10-1296
Activity:
IKK inhibitor
Chemical Name:
(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
Molecular Weight:
207.27
Molecular Formula:
C10H9NO2S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the BAY 11-7082 | IKK inhibitor to your wish list.