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Bioactive Lipids

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  • 1-Aminobenzotriazole | Cytochrome P450 inhibitor
    1-Aminobenztriazole (1614-12-6) is a pan-specific cytochrome P450 inhibitor acting as a suicide substrate.1,2 Blocks omega-oxidation of arachidonic acid but not its epoxidation.3  References/Citations 1) Mugford et al...

  • 2-Bromopalmitic acid | Palmitoylation inhibitor
    2-Bromopalmitic acid (18263-25-7) inhibits protein S-palmitoylation.1   References/Citations 1) Tsukamoto et al. (2013), Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells; PLoS...

  • A-769662 is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator
    A-769662 (844499-71-4) is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator.  Activates AMPK by binding to the β and γ subunits and not the AMP binding site.1 EC50=0.8 mM for...

  • AH-6809 | 33458-93-4 | Structure | Supplier
    AH-6809 (33458-93-4) is a selective PGE2 receptor (EP1) antagonist. At concentrations higher than 10 μM PGD2 and TXA2 receptors are also blocked. References/Citations1) Coleman in Prostaglandins and Related Substances: A...

  • AH-7614 | GPR120 antagonist
    AH-7614 (6326-06-3) is a selective antagonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pIC50s= 7.1 and 1. References/Citations1) Sparks et al. (2014), Identification of diarylsulfonamides as agonists of...

  • Anandamide | Endogenous cannabinoid
    Anandamide (94421-68-8) is an endogenous cannabinoid receptor agonist.1-3 Ki=89 nM for CB1 and 371 nM for CB2 receptors. References/Citations1) Devane et al. (1992), Isolation and structure of a brain constituent that binds...

  • Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis1. Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been...

  • Bestatin HCl | 65391-42-6 | Structure | Supplier
    Bestatin HCl (65391-42-6) inhibits leucine aminopeptidase and aminopeptidases B and N. Inhibits leukotriene A4 hydrolase. Displays immunostimulant activity via activation of macrophages and T lymphocytes. Displays antitumor...

  • BML-111 | LXA agonist, antiinflammatory
    BML-111 (78606-80-1) novel truncated analog of lipoxin A4 which retains anti-inflammatory activity.1 Inhibits LTB4-induced leukocyte chemotaxis, IC50=5 nM).1 Attenuates hemorrhagic shock-induced acute lung injury in a rat...

  • C2Ceramide | 3102-57-6 | Structure | Supplier
    C2 Ceramide (3102-57-6) is a cell permeable ceramide analog. Induces apoptosis in a variety of cell types. Stimulates ceramide-activated protein phosphatases. Activates ceramide-activated protein kinases...

  • $50.00
    C2 Dihydroceramide (13031-64-6) is a negative control for C2-ceramide (cat.# 10-1181).1,2 Induces autophagy ina variety of cell types.3,4 References/Citations1) Bielawska et al. (1993) Selectivity of ceramide-mediated...

  • C22 Ceramide | MCSR inhibitor
    C22 Ceramide is a  long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids...

  • C8-Ceramide | Protein kinase activator
    C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1 Induces apoptosis.2 Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver...

  • Cerulenin | Fatty Acid Synthase inhibitor
    Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM.1 Cerulenin produces...

  • DCH-Gly | Structure | Supplier
    DCHA-Gly is an endogenous lipoamino acid.

  • Dihydrosphingosine | PKC inhibitor, Sphingosine precursor
    Dihydrosphingosine (764-22-7) is a biosynthetic precursor of sphingosine. Inhibitor of protein kinase C1 and phospholipases A2 and D2. References/Citations1) Merrill et al. (1989), Structural requirements for long-chain...

  • EPA free acid | 10417-94-4 | Structure | Supplier
    EPA free acid (10417-94-4) dietary enrichment may have anti-inflammatory effects by inhibiting the 5-lipoxygenase pathway and LTB4-mediated neutrophil functions.1 Displays various cardiovascular protective properties...

  • Epoxomicin | 134381-21-8 | Structure | Supplier
    Epoxomicin (134381-21-8) is a potent, selective and cell permeable irreversible inhibitor of the 20S proteasome.1 It does not inhibit non-proteasomal proteases such as papain, chymotrypsin, trypsin, calpain and cathepsin B...

  • Erucamide | Antidepressant/Anti-anxiety
    Erucamide (112-84-5) is an endogenous fatty acid amide.  It was able to ameliorate depression and anxiety-like behaviors in several mouse models.  Significantly lowered levels of circulating adrenocorticotrophic...

  • Fatostatin | 125256-00-0 | Structure | Supplier
    Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight,...

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