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BiochemicalTargets

Bioactive Lipids

Bioactive lipids are a diverse group of endogenous molecules that are involved in a wide array of biological processes. Members of this family include prostaglandins, leukotrienes, sphingolipids, fatty acids and their metabolic products, steroids, phospholipids, vitamins, endocannabinoids, and acylglycerol derivatives.

Cholesterol & analogues/metabolites

T0901317 | LXR Agonist

T0901317 (293754-55-9) is a  potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM.1   Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in

Docosanoids

Synaptamide | Endogenous agonist at GPR110

CAS:
162758-94-3
Catalog Number:
10-1194
Activity:
Endogenous agonist at GPR110
Chemical Name:
N-Docosahexaenoylethanolamide
Alternate Names:
DHA-ethanolamide
Molecular Weight:
371.56
Molecular Formula:
C24H37NO2
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Colorless to yellow oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-80°C, protect from exposure to air.
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored under inert gas at -80°C for up to 3 months.
Shipping Code:
Dry Ice

DCHA-Gly | Endogenous lipo-amino acid

CAS:
132850-40-9
Catalog Number:
10-1316
Activity:
Endogenous lipo-amino acid
Chemical Name:
N-Docosahexaenoylglycine
Molecular Weight:
385.55
Molecular Formula:
C24H35NO3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Yellowish waxy solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Product is prone to air oxidation.  Solutions in degassed DMSO or ethanol may be stored at -20° for up to 1 month under a nitrogen/argon atmosphere.
Shipping Code:
RT

NA-Gly | GPR18 agonist

CAS:
179113-91-8
Catalog Number:
10-1200
Activity:
GPR18 agonist
Alternate Names:
N-Arachidonylglycine
Chemical Name:
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)glycine
Molecular Weight:
361.53
Molecular Formula:
C22H35NO3
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Beige waxy solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Product is subject to oxidation. Solutions in degassed DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
Blue Ice

Eicosanoids

N-Arachidonoyldopamine | Endogenous TRPV1 activator

CAS:
199875-69-9
Catalog Number:
10-1479
Activity:
Endogenous TRPV1 activator
Chemical Name:
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)dopamine
Alternate Name:
NADA; AA-DA
Molecular Weight:
439.63
Molecular Formula:
C28H41NO3
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Pale yellow viscous oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-80° (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Subject to air oxidation Solutions in DMSO may be stored at -80° under an inert atmosphere for up to 1 month.
Shipping Code:
Blue Ice

N-Eicosanoyl serotonin | Neuroprotective

Catalog Number:
10-3631
Activity:
Neuroprotective
Chemical Name:
Eicosanoyl-5-hydroxytryptamide
Alternate Name:
Eicosanoyl serotonin, EHT
Molecular Weight:
470.73
Molecular Formula:
C30H50N2O2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase supplied. Protect from air. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Anandamide | Endogenous cannabinoid

CAS:
94421-68-8
Catalog Number:
10-2009
Activity:
Endogenous cannabinoid
Alternate Names:
Arachidonoylethanolamide; AEA
Chemical Name:
N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Molecular Weight:
347.54
Molecular Formula:
C22H27NO2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml).
Physical Properties:
Colorless oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-80°C
Stability:
Stable for 1 year from date of purchase as supplied. Subject to oxidation – protect from air. Solutions in degassed DMSO or ethanol may be stored under nitrogen or argon at -80°C for up to 1 month.
Shipping Code:
Blue Ice

Fatty Acid Binding Protein

HTS01037 | FABP inhibitor

CAS:
682741-29-3
Catalog Number:
10-1453
Activity:
FABP inhibitor
Chemical Name:
4-[(3-Carboxy-1-oxo-2-propen-1-yl)amino]-[2,2’-bithiophene]-5-carboxylic acid, 5-methyl ester
Molecular Weight:
337.37
Molecular Formula:
C14H11NO5S2
Solubility:
Soluble in DMSO (up to 50 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Fatty acids

N-Myristoylglycine | Endogenous brown fat-inducing lipid

CAS:
14246-55-0
Catalog Number:
10-3783
Activity:
Endogenous brown fat-inducing lipid
Chemical Names:
N-Tetradecanoylglycine; 2-(Tetradecanoylamino)acetic acid
Alternate Name:
Myristoyl glycine; NSC622050; Myr-Gly
Molecular Weight:
285.43
Molecular Formula:
C16H31NO3
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Acetyl-Coenzyme A 3Li | Acetylation and fatty acid biosynthesis cofactor

CAS:
75520-41-1
Catalog Number:
10-5384
Activity:
Cofactor for cellular metabolism/Acetyl donor
Chemical Name:

Acetyl-CoA

Molecular Weight:
881.42
Molecular Formula:
C23H35Li3N7O17P3S·3H2O
Solubility:
Soluble in water (10 mg/ml)
Physical Properties:
White solid
Purity:
90% (enzymatic)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in water may be stored at -20°C for up to 2 weeks.
Shipping Code:
RT

Fasnall HCl | Fatty acid synthase inhibitor

CAS:
929978-58-5
Catalog Number:
10-1613
Activity:
Fatty acid synthase inhibitor
Chemical Name:
5,6-Dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]thieno[2,3-d]pyrimidin-4-amine benzenesulfonate hydrochloride
Molecular Weight:
374.93
Molecular Formula:
C19H22N4S • HCl
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 45 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Lipid biosynthesis inhibitors

L-Cycloserine | Serine palmitoyltransferase inhibitor

L-Cycloserine (339-72-0) down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase).1 The L isomer was shown to be 100-fold more potent than the D isomer at

HET0016 | 20-HETE biosynthesis inhibitor

HET0016 (339068-25-6) inhibits 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis via omega oxidation of arachidonic acid mediated by CYP4A and 4F (IC50=8.9 nM in human renal microsomes).1 It displays

Lipid metabolism inhibitors

S07-2010 | pan-AKR1C inhibitor

S07-2010 (1223194-71-5) is a pan-aldo-keto reductase 1C (AKR1C) inhibitor (IC50’s for AKR1C isoforms: 1C1 = 470 nM, 1C2 = 730 nM, 1C3 = 190 nM, 1C4

PF-543 HCl | Sphingosine kinase-1 inhibitor

PF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1).1 It induced autophagy in head and neck squamous

NG-497 | Human ATGL inhibitor

CAS:
2598242-66-9
Catalog Number:
10-4626
Activity:
Human ATGL inhibitor
Chemical Names:
Isopropyl 6-(4-ethoxyphenyl)-4-methoxypicolinate
Molecular Weight:
315.37
Molecular Formula:
C18H21NO4
Solubility:
Soluble in DMSO (25 mg/ml with warming); Ethanol (20 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Lipid receptor agonists & antagonists

Gue1654 | OXE-R biased antagonist

Gue1654 (397290-30-1) is a biased antagonist for the oxoeicosanoid receptor 1 (OXE-R, GPR170)1, the receptor for 5-Oxo-ETE, a proinflammatory eicosanoid2. It selectively inhibits Gβγ but not

YL-365 | GPR34 antagonist

YL-365 is a potent (IC50 = 17 nM) and selective antagonist of GPR34, a GPCR for lysophosphatidylserine.1 GPR34 is highly expressed in various immune cells and

Picotamide | Antiplatelet agent

CAS:
32828-81-2
Catalog Number:
10-3925
Activity:
Antiplatelet agent
Molecular Weight:
376.41
Molecular Formula:
C21H20N4O3
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Octadecanoids

Oleamide | Endogenous sleep-inducing lipid

CAS:
301-02-0
Catalog Number:
10-2923
Activity:
Endogenous sleep-inducing lipid
Chemical Names:
9Z-Octadecenamide; cis-9-Octadecenamide; Oleic acid amide
Molecular Weight:
281.48
Molecular Formula:
C18H35NO
Solubility:
Soluble in DMSO (25 mg/ml); Ethanol (40 mg/ml)
Physical Properties:
White to off-white solid
Purity:
99% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

N-Oleoylphenylalanine | Endogenous Uncoupler of Mitochondrial Respiration

CAS:
136560-78-6
Catalog Number:
10-1602
Activity:
Endogenous Uncoupler of Mitochondrial Respiration
Chemical Name:
N-Oleoyl Phe
Alternate Names:
NOPA, C18-1-Phe
Molecular Weight:
429.64
Molecular Formula:
C27H43NO3
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Off-white solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:

Blue Ice

PAF

WEB-2086 | PAF receptor antagonist

CAS:
105219-56-5
Catalog Number:
10-1389
Activity:
PAF receptor antagonist
Alternate Names:
Apafant
Chemical Name:
4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine
Molecular Weight:
455.96
Molecular Formula:
C22H22ClN5O2S
Solubility:
Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Ginkgolide B | PAF receptor antagonist

CAS:
15291-77-7
Catalog Number:
10-1080
Activity:
PAF antagonist
Alternate Names:
BN 52021
Chemical Name:
Natural product isolated from Ginko biloba
Molecular Weight:
424.41
Molecular Formula:
C20H24O10
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
Shipping Code:
RT

Phosphatidic acid

Phosphatidylinositol (50%) | Endogenous lipid

CAS:
97281-52-2
Catalog Number:
10-2779
Activity:
Endogenous lipid
Alternate Names:
L-α-Phosphatidylinositol
Chemical Name:
1,2-Diacyl-sn-glycero-3-phosphoinositol monopotassium salt
Molecular Weight:
896.18 (linoleoyl form)
Molecular Formula:
C45H77O13PK
Solubility:
Soluble in Chloroform.
Physical Properties:
Off-white or tan solid
Purity:
50% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied.
Shipping Code:
RT

Lysophosphatidic acid (Oleyl form) | Endogenous LPA receptor agonist

CAS:
325465-93-8
Catalog Number:
10-1449
Activity:
Endogenous LPA receptor agonist
Alternate Names:
LPA Na; 1-Oleoyl-lysophosphatidic acid, sodium salt
Chemical Name:
1-Oleoyl-2-hydroxy-sn-glycerol-3-phosphate, sodium
Molecular Weight:
458.51
Molecular Formula:
C21H40O7P
Solubility:
Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 10 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

Phosphatidylethanol | PLD assay standard

CAS:
Catalog Number:
10-1410
Activity:
PLD assay standard
Chemical Name:
1-Palmitoyl-2-oleoyl-sn-glycerol-3-phosphoethanol
Molecular Weight:
701.99
Molecular Formula:
C39H74O8P
Solubility:
Soluble in Chloroform (up to 10 mg/ml).
Physical Properties:
Viscous oil / waxy solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Phosphatidylethanol is subject to oxidation and must be protected from exposure to air. Solutions in chloroform may be stored at -20° for up to 3 months.
Shipping Code:
RT

Sphingolipids

C6-NBD Ceramide | Fluorescent probe for the Golgi apparatus

CAS:
94885-02-6
Catalog Number:
10-5496
Activity:
Fluorescent probe for the Golgi apparatus
Chemical Names:
N-[7-(4-Nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine; N-(NBD-aminohexanoyl) D-erythro-sphingosine
Molecular Weight:
575.75
Molecular Formula:
C30H49N5O6
Solubility:
Soluble in DMSO (35 mg/mL)
Physical Properties:
Orange solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

C22 Ceramide | MCSR inhibitor

CAS:
869501-30-4
Catalog Number:
10-1615
Activity:
MCSR inhibitor
Molecular Weight:
622.06
Molecular Formula:
C40H79NO3
Solubility:
Soluble in DMSO (up to 12 mg/ml with warming) or in Ethanol (up to 10 mg/ml with warming
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Steroids

Allopregnanolone | GABA-A positive allosteric modulator

CAS:
516-54-1
Catalog Number:
10-3489
Activity:
GABA-A positive allosteric modulator
Chemical Name:
(3α,5α)-3-Hydroxy-pregnan-20-one
Alternate Name:
(3α,5α)-Tetrahydroprogesterone; 3-OH-DHP
Molecular Weight:
318.49
Molecular Formula:
C21H34O2
Solubility:
Soluble in DMSO (up to 32 mg/ml) or in Ethanol (up to 32 mg/ml)
Physical Properties:
White or off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Other

Cafestol | Neuroprotective

Cafestol (469-83-0) is a bioactive diterpene found in coffee.1 It displays a number of interesting protective effects including stimulation of glutathione S-transferase activity1, and protection against

N-Myristoylglycine | Endogenous brown fat-inducing lipid

CAS:
14246-55-0
Catalog Number:
10-3783
Activity:
Endogenous brown fat-inducing lipid
Chemical Names:
N-Tetradecanoylglycine; 2-(Tetradecanoylamino)acetic acid
Alternate Name:
Myristoyl glycine; NSC622050; Myr-Gly
Molecular Weight:
285.43
Molecular Formula:
C16H31NO3
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Oleoylethanolamide | GPR119 agonist: stimulates lipolysis

CAS:
111-58-0
Catalog Number:
10-1475
Activity:
GPR119 agonist: Stimulates lipolysis
Chemical Name:
N-(2-Hydroxyethyl)-9Z-octadecenamide
Alternate Names:
OEA
Molecular Weight:
325.53
Molecular Formula:
C20H39NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT