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Lipid receptor agonists and antagonists

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  • AH-6809 | 33458-93-4 | Structure | Supplier
    $60.00
    AH-6809 (33458-93-4) is a selective PGE2 receptor (EP1) antagonist. At concentrations higher than 10 μM PGD2 and TXA2 receptors are also blocked. References/Citations1) Coleman in Prostaglandins and Related Substances: A...

  • AH-7614 | GPR120 antagonist
    $45.00
    AH-7614 (6326-06-3) is a selective antagonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pIC50s= 7.1 and 1. References/Citations1) Sparks et al. (2014), Identification of diarylsulfonamides as agonists of...

  • GRI-977143 | 325850-81-5 | Structure | Supplier
    $80.00
    GRI-977143 (325850-81-5) is a selective agonist of the lysophosphatidic acid-2 (LPA2) receptor. Displays antiapoptotic activity.1 Rescues apoptotically condemned cells from death and injury caused by high-dose...

  • H2L5186303 | LPA2 antagonist
    $75.00
    H2L5186303 (139262-76-3) is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist.  IC50 = 8.9 nM, 1230 nM and 27.35 μM for LPA2, LPA3, and LPA1 respectively.1,2 References/Citations 1) Fells et...

  • LY-171883 | 88107-10-2 | Structure | Supplier
    $60.00
    LY-171883 (88107-10-2) is a selective and orally active leukotriene D4 (LTD4) antagonist (Ki = 0.63 μM).1 It is also an activator of peroxisome proliferator-activated receptors (PPAR's).2,3 References/Citations1) Fleisch...

  • MK-571 | 115104-28-4 | Structure | Supplier
    $60.00
    MK-571 (115104-28-4) is a potent (EC50 = 1.3nM) and selective Leukotriene D4 antagonist (LTD4)1 displaying inverse agonist activity2. Blocks binding of LTD4 to human (Ki = 0.22 nM) and guinea pig (Ki = 2.1 nM) lung membranes...

  • WEB-2086 | 105219-56-5 | Structure | supplier
    $40.00
    WEB-2086 (105219-56-5) is a potent and selective antagonist of the platelet activating factor (PAF) receptor (Ki = 16.3 nM).1 Displays an activity profile which includes antiinflammatory, antiangiogenesis and anticancer...

  • Zafirlukast | 107753-78-6 | Structure | Supplier
    $50.00
    Zafirlukast (107753-78-6) is a competitive and selective leukotriene receptor antagonist1. Also inhibits calcium ionophore induced production of leukotriene B4 and leukotriene C4, which suggests a potential 5-LO inhibitory...

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