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Sphingolipids

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  • C2Ceramide | 3102-57-6 | Structure | Supplier
    $50.00
    C2 Ceramide (3102-57-6) is a cell permeable ceramide analog. Induces apoptosis in a variety of cell types. Stimulates ceramide-activated protein phosphatases. Activates ceramide-activated protein kinases...

  • $50.00
    C2 Dihydroceramide (13031-64-6) is a negative control for C2-ceramide (cat.# 10-1181).1,2 Induces autophagy ina variety of cell types.3,4 References/Citations1) Bielawska et al. (1993) Selectivity of ceramide-mediated...

  • C22 Ceramide | MCSR inhibitor
    $55.00
    C22 Ceramide is a  long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids...

  • C8-Ceramide | Protein kinase activator
    $40.00
    C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1 Induces apoptosis.2 Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver...

  • Dihydrosphingosine | PKC inhibitor, Sphingosine precursor
    $30.00
    Dihydrosphingosine (764-22-7) is a biosynthetic precursor of sphingosine. Inhibitor of protein kinase C1 and phospholipases A2 and D2. References/Citations1) Merrill et al. (1989), Structural requirements for long-chain...

  • Miglustat HCl | Alpha-glucosidase inhibitor
    $110.00
    Miglustat HCl (210110-90-0) is an orally active ceramide-specific glycosyltransferase and α-glucosidase I and II inhibitor.1 Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of...

  • N,N-Dimethylsphingosine | Inhibits sphingosine kinase
    $57.00
    N,N-Dimethylsphingosine (119567-63-4) is a synthetic derivative of D-erythro-sphingosine (Cat.# 10-2287). Endogenous sphingolipid.1 Inhibits sphingosine kinase (IC50 = 5 μM).2 N,N-Dimethylsphingosine induces...

  • Phytosphingosine | 554-62-1 | Structure | supplier
    $45.00
    Phytosphingosine (554-62-1) displays antibacterial activity.1 Can be taken up by E. coli and S. aureus and induce ultrastructural damage.2 References/Citations1) Fischer et al. (2012), Antibacterial activity of...

  • Sphingosine | PKC inhibitor
    $70.00
    Sphingosine (123-78-4) is an inhibitor of protein kinase C (IC50 = 1-3 μM).1 It is abundant in cell membranes and is an important mediator in various biochemical pathways.2-4 References/Citations1) Merrill et al., (1989)...

  • Sphingosine-1-phosphate | EDG receptor ligand
    $65.00
    Sphingosine-1-phosphate (26993-30-6) is an endogenous sphingolipid metabolite known to be involved in many cellular responses including angiogenesis, vascular maturation, cardiac development and immunity. These effects are...

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