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Bongkrekic Acid | Inhibits MPT pore opening

CAS:
11076-19-0
Catalog Number:
10-2751
Activity:
Inhibits MPT pore opening
Chemical Name:
3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic acid
Molecular Weight:
486.61
Molecular Formula:
C28H38O7
Solubility:
Miscible with DMSO.
Physical Properties:
Solution at 1 mg/mL (2 mM) in 0.01M Tris buffer pH 7.5 (contains 1 mg net bongkrekic acid per mL)
Purity:
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
Blue Ice

Bongkrekic acid (11076-19-0) is a p potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT).1 Inhibits mitochondrial permeability transition pore opening.2,3 Delivery of bongkrekic acid to the mitochondria prevents apoptosis in HeLa cells.4

References/Citations:

1) Ziegler et al. (1993), The adenine nucleotide translocase modulates oligomycin-induced quenching of pyranine fluorescence in submitochondrial particles; J. Biol. Chem., 268 25320
2) Marchetti et al. (1996), Mitochondrial permeability transition triggers lymphocyte apoptosis; J. Immunol., 157 4830
3) Zamzami et al. (1996), Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis; FEBS Lett., 384 53
4) Yamada et al. (2013), Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells; J. Pharm. Sci., 102 1008

Bongkrekic Acid | Inhibits MPT pore opening is also available in the Cellular Metabolism Library.
CAS:
11076-19-0
Catalog Number:
10-2751
Activity:
Inhibits MPT pore opening
Chemical Name:
3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic acid
Molecular Weight:
486.61
Molecular Formula:
C28H38O7
Solubility:
Miscible with DMSO.
Physical Properties:
Solution at 1 mg/mL (2 mM) in 0.01M Tris buffer pH 7.5 (contains 1 mg net bongkrekic acid per mL)
Purity:
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
Blue Ice

Safety Data Sheet:

N/A

Product Data Sheet:

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