my account
Login
  Loading... Please wait...

Product Details

C22 Ceramide | MCSR inhibitor

C22 Ceramide is a  long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids. C22-ceramide is an endogenous signaling lipid which specifically inhibits MCSR with no effect on unfolded protein responses within the mitochondria.1 Hearts overexpressing Acyl CoA synthetase1 contain elevated levels of C22-ceramide.2

References/Citations

1) Kim et al. (2016), Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response; Cell, 166 1539
2) Goldenberg et al. (2016), Acyl-CoA synthase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male vs. female mice; J. Mol. Cell. Cardiol., 94 1

swipe
C22 Ceramide | Structure | supplier

Catalog#  10-1615

$55.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
Catalog Number:
10-1615
Activity:
MCSR inhibitor
Molecular Weight:
622.06
Molecular Formula:
C40H79NO3
Solubility:
Soluble in DMSO (up to 12 mg/ml with warming) or in Ethanol (up to 10 mg/ml with warming
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
FeaturedDescription:
Endogenous signaling lipid which specifically inhibits mitochondrial-to-cytosolic stress response (MCSR) with no effect on unfolded protein responses within the mitochondria
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the C22 Ceramide | MCSR inhibitor to your wish list.