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BiochemicalTargets

Calcium Signaling

Calcium regulation is critical for cellular function, playing direct and indirect roles in many different cellular processes. Fluctuations in extracellular calcium levels are sensed by certain GPCRs and transduced by the phospholipase C pathway. Inside the cell, where calcium pools are regulated by the ER and mitochondria, it is utilized as a second messenger for fundamental events such as growth, apoptosis, and protein synthesis and function. Many small molecule tools can used for studying this pathway including ionophores. calcium channel blockers and activators, calmodulin modulators, calcium ATPases, and more.

Calmodulin

Phenoxybenzamine HCl | Calmodulin antagonist

CAS:
63-92-3
Catalog Number:
10-1237
Activity:
Calmodulin antagonist
Chemical Name:
N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride
Molecular Weight:
340.29
Molecular Formula:
C18H22ClNO HCl
Solubility:
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 15 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

STO-609 | CAMKK inhibitor

CAS:
1173022-21-3
Catalog Number:
10-1036
Activity:
CAMKK inhibitor
Chemical Name:
7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
Molecular Weight:
374.35
Molecular Formula:
C19H10N2O3·CH3COOH
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Calcium Channels

YM-58483 | CRAC channel blocker

CAS:
223499-30-7
Catalog Number:
10-2935
Activity:
CRAC channel blocker
Chemical Names:
N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide
Alternate Name:
BTP2
Molecular Weight:
421.32
Molecular Formula:
C15H9F6N5OS
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Manidipine dihydrochloride | Calcium channel blocker

CAS:
89226-75-5
Catalog Number:
10-2045
Activity:
Calcium channel blocker
Chemical Names:
5-O-[2-(4-Benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
Alternate Name:
CV-4093
Molecular Weight:
683.63
Molecular Formula:
C35H38N4O6·2HCl
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Nimodipine | L-type calcium channel blocker

CAS:
66085-59-4
Catalog Number:
10-1321
Activity:
L-type calcium channel blocker
Chemical Name:
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methyloxyethyl 1-methylethyl ester
Alternate Names:
BAY-e 9736
Molecular Weight:
418.44
Molecular Formula:
C21H26N2O7
Solubility:
Soluble in DMSO (up to 40 mg/ml)
Physical Properties:
Pale-yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Ionophores & chelators

4-Bromo-A23187 | Non-fluorescent calcium ionophore

CAS:
76455-48-6
Catalog Number:
10-5590
Activity:
Non-fluorescent calcium ionophore
Chemical Names:
4-Bromocalcimycin
Alternate Name:
4-Bromo-calcium ionophore A23187
Molecular Weight:
602.53
Molecular Formula:
C29H36BrN3O6
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Ionomycin Ca | Calcium Ionophore

CAS:
56092-82-1
Catalog Number:
10-2078
Activity:
Calcium ionophore
Fermentation product from:
Streptomyces conglobatus
Molecular Weight:
747.07
Molecular Formula:
C41H70O9·Ca
Solubility:
Soluble in DMSO (10 mg/ml); Ethanol (30 mg/ml)
Physical Properties:
White solid
Purity:
99% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

BAPTA-free acid | Extracellular calcium sponge

CAS:
85233-19-8
Catalog Number:
10-1204
Activity:
Extracellular calcium sponge
Chemical Name:
1,2-bis-(2-Aminophenoxy)ethane-N,N,N’,N,-tetraacetic acid
Molecular Weight:
476.43
Molecular Formula:
C22H24N2O10
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
97% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Ryanodine Receptor

Levetiracetam | Anticonvulsant

CAS:
102767-28-2
Catalog Number:
10-2040
Activity:
Anticonvulsant
Chemical Name:
2(S)-(2-Oxopyrrolidin-1-yl)butyramide
Molecular Weight:
170.21
Molecular Formula:
C29H14N2O2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Dantrolene Na | SR calcium release inhibitor

CAS:
14663-23-1
Catalog Number:
10-2208
Activity:
SR calcium release inhibitor
Chemical Name:
1-[(5-(p-Nitrophenyl)furfurylidene)amino]hydantoin sodium salt
Molecular Weight:
336.23
Molecular Formula:
C14H9N4O5 Na
Solubility:
Soluble in DMSO (up to 3 mg/ml) or in a 1:1 mix of DMF and Ethanol (up to 20 mg/ml)
Physical Properties:
Orange solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF/ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

SERCA

CDN1163 | SERCA activator

CAS:
892711-75-0
Catalog Number:
10-4627
Activity:
Allosteric SERCA activator
Chemical Names:
4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
Molecular Weight:
320.39
Molecular Formula:
C20H20N2O2
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Azoramide | UPR modulator

CAS:
932986-18-0
Catalog Number:
10-4629
Activity:
UPR modulator
Chemical Name:
N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide
Molecular Weight:
308.83
Molecular Formula:
C15H17ClN2OS
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in ethanol (up to at least 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Thapsigargin | SERCA inhibitor

CAS:
67526-95-8
Catalog Number:
10-2105
Activity:
SERCA inhibitor
Chemical Name:
Isolated from Thapsia garganica
Molecular Weight:
650.77
Molecular Formula:
C34H50O12
Solubility:
Soluble in DMSO (up to 65 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Colorless waxy solid / film
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT

Other

YM-58483 | CRAC channel blocker

CAS:
223499-30-7
Catalog Number:
10-2935
Activity:
CRAC channel blocker
Chemical Names:
N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide
Alternate Name:
BTP2
Molecular Weight:
421.32
Molecular Formula:
C15H9F6N5OS
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

QNZ | NFkB inhibitor / Store operated calcium entry

CAS:
545380-34-5
Catalog Number:
10-4009
Activity:
NF-kB inhibitor / Store-operated calcium entry
Chemical Name:
4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine
Alternate Name:
EVP4593
Molecular Weight:
356.42
Molecular Formula:
C22H20N4O
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT