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Autophagy

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  • DBeQ | 177355-84-9 | Structure | Supplier
    $65.00
    DBeQ (177355-84-9) is a potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks ubiquitin-dependent protein clearance pathways. Cell...

  • Itraconazole | Autophagy inducer / Inhibits glioblastoma growth
    $40.00
    Itraconazole (84625-61-6) inhibits the conversion of lanosterol to ergosterol via inhibition of the 14-α demethylase, a cytochrome P-450 enzyme.1 Clinically useful antifungal agent. It inhibits the proliferation of...

  • Salirasib | 162520-00-5 | Structure | Supplier
    $30.00
    Salirasib (162520-00-5) is a synthetic farnesylcysteine mimetic that inhibits ras proteins1,2 via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains3.  It has been...

  • Spautin-1 | 1262888-28-7 | Structure | Supplier
    $70.00
    Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1...

  • STF-62247 | 315702-99-9 | Structure | Supplier
    $55.00
    STF-62247 (315702-99-9) specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC50=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by...

  • Vinblastine sulfate | Microtubule depolymerizer
    $48.00
    Vinblastine sulfate (143-67-9) is a semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation.1 Inhibits normal microtubule assembly and induces aberrant...

  • YM-155 | 781661-94-7 | Structure | Supplier
    $58.00
    YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on...

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