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Cell Cyle

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  • 10058-F4 | 403811-55-2 | Structure | Supplier
    10058-F4 (403811-55-2) effectively disables c-Myc by inhibiting the c-Myc-Max association and function1. It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase...

  • Aphidicolin | DNA polymerase inhibitor
    Aphidicolin (38966-21-1) specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases1. Arrests cell cycle at...

  • Apicidin | HDAC inhibitor
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

  • Apigenin | 520-36-5 | Structure | Supplier
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

  • CFM-4 | 331458-02-7 | Structure | Supplier
    CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM)1. Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of...

  • Dasatinib | Src and Bcr/Abl inhibitor
    Dasatinib (302962-49-8) inhibits Src, Bcl/Abl and Lyn tyrosine kinases (IC50= 0.55, 3.0 and 8.5 nM respectively).1,2 Suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell...

  • Dehydrozingerone | Glutathione sponge
    Dehydrozingerone (1080-12-2) is a structural half analog of curcumin (Cat.# 10-1243) and is isolated from ginger rhizomes. Dehydrozingerone displays antioxidant, antibacterial and antifungal properties.1 It has also been...

  • Docetaxel | Microtubule stabilizing agent
    Docetaxel (114977-28-5) is an antimitotic chemotherapeutic which inhibits via reversible high-affinity binding to microtubules1. Induces apoptosis in a variety of cancer cell lines2 however, tumor cells can quickly develop...

  • Epothilone B | Microtubule stabilizing agent
    Epothilone B (152044-54-7) induces microtubule polymerization. Causes cell cycle arrest at the G2-M transition (EC50 = 32 nM for HeLa cells). Induces apoptosis. Cell permeable. References/Citations1) Goodin et al. (2004),...

  • Etoposide | 33419-42-0 | Structure | Supplier
    Etoposide (33419-42-0) is a chemotherapeutic agent that forms a ternary complex with DNA and topoisomerase II, preventing re-ligation of DNA strands causing DNA cleavage. Etoposide blocks the cell cycle in S-phase and...

  • Fascaplysin | 114718-57-2 | Structure | Supplier
    Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1...

  • Flavopiridol HCl | CDK inhibitor
    Flavopiridol HCl (131740-09-5) is a cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase.1 Potentiates (100-200 nM) PMA-induced apoptosis in HL-60 and U937 cells.2 Potentiates the effects...

  • Genistin | Genistein glycoside
    Genistin (529-59-9) is a novel selective inhibitor of terminal deoxyribonucleotidyl-transferase.1 Disrupts cell cycle and induces apoptosis in human ovarian cancer SK-OV-3 cells.2 Inhibits UV light-induced plasmid DNA damage...

  • Griseofulvin | Inhibitor of centrosomal clustering
    Griseofulvin (126-07-8) is an antifungal antimitotic agent. Induces apoptosis of human germ cell tumor cells via disruption of connexin 43/tubulin association concomitant with enhanced translocation of connexin 43 from the...

  • K-858 | 72926-24-0 | Structure | Supplier
    K-858 (72926-24-0) is a selective mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM) which acts in an ATP-noncompetitive manner1,2. It is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily...

  • Leptomycin B | Nuclear export inhibitor
    Leptomycin B (87081-35-4) is an inhibitor of nuclear export of proteins. Acts via covalent binding to and inhibiting CRM1/exportin-11. Inhibits the nuclear export of the HIV regulatory protein Rev2. Leptomycin B stabilizes...

  • ML-60218 | Structure | Supplier
    A broad spectrum inhibitor of RNA polymerase III from S. Cerevisiae as well as from human cells, IC50=32 mM and 27 mM respectively.1   Combined treatment with ML-60218 and an HDAC inhibitor caused augmented...

  • Myriocin | Blocks sphingolipid biosynthesis
    Myriocin (35891-70-4) is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 Myriocin was found to suppress melanoma cell...

  • NSC 95397 | 93718-83-3 | Structure | Supplier
    NSC 95397 (93718-83-3) is a potent and selective inhibitor of Cdc25 phosphatase (Ki  = 32, 96 and 40 nM for Cdc25A, B and C respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M...

  • NSC663284 | 383907-43-5 | Structure | Supplier
    NSC663284 (383907-43-5) is a potent, selective and irreversible inhibitor of CDC25 phosphatases, Ki=29, 95 and 89 nM for human CDC25A, B2 and C respectively and >20- and >450-fold selective over VHR and PTP1B1. Arrests...

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