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Epigenetics

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  • 2'-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor
    $52.00
    2'-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors1. Like 5'-Azacytidine (Cat.# 10-1267) and decitabine (Cat.# 10-2412),...

  • C-646 | 328968-36-1 | Structure | Supplier
    $80.00
    C-646 (328968-36-1) is a potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. C-646 enhances fear extinction memory and synaptic plasticity in...

  • CUDC-101 | Dual HDAC and EGFR inhibitor
    $70.00
    A novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2,  IC50 = 4.4, 2.4 and 15.7 nM respectively.1 It not only blocks EGFR and HER2 but...

  • Decitabine | DNA hypomethylation agent
    $90.00
    Decitabine (2353-33-5) inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Decitabine stimulates osteogenic differentiation of human bone...

  • DZNep | Methyltransferase inhibitor
    $142.00
    DZNep (102052-95-9) is a potent histone methyltransferase inhibitor which decreases global histone methylation.1 Inhibits trimethylation of H3K27 and H4K20 in vitro.1 Selectively induces apoptosis in multiple cancer cell...

  • JIB-04 | Structure | Supplier
    $60.00
    JIB-04 (199596-05-9) is a novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B,...

  • Mithramycin A | Transcription inhibitor
    $40.00
    Mithramycin A (18378-89-7) inhibits DNA methyl transferase.1 A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibiting their expression.2...

  • MS-275 (Entinostat) | HDAC inhibitor
    $50.00
    MS-275 (Entinostat - 209783-80-2) is a potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 100 μM).1 In vivo, MS-275, has been shown to inhibit tumor growth via induction...

  • Panobinostat | HDAC inhibitor
    $60.00
    Panobinostat (404950-80-7) is a potent inhibitor of class I and II HDACs.1 Cotreatment with panobinostat and an HSP90 inhibitor caused synergistic apoptosis in human CML-BC and AML cells.2 A potent antimyeloma...

  • PBIT | JARID1 lysine demethylase inhibitor
    $54.00
    PBIT (2514-30-9) is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates...

  • Romidepsin | HDAC inhibitor
    $200.00
    Romidepsin (2-128517-07-7) is a potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively.1 Induces apoptosis in a variety of cell...

  • SAHA | 149647-78-9 | Structure | Supplier
    $48.00
    SAHA (149647-78-9) is a potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. SAHA synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable...

  • Sirtinol | 410536-97-9 | Structure | Supplier
    $90.00
    Sirtinol (410536-97-9) is an inhibitor of sirtuin family enzymes including human SIRT1 (IC50=60 μM), human SIRT2 (IC50=58 μM), and yeast Sir2 (IC50=48 μM) with no inhibition of human HDAC1. Active in vivo and in...

  • TC-E 5033 | 17328-16-4 | Structure | Supplier
    $60.00
    TC-E 5003 (17328-16-4) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor, IC50 = 1.5 μM. Displays no activity against CARM1 and Set7/9 methyltransferases. TC-E 5003 inhibits growth of MCF7a breast...

  • Trichostatin A | HDAC inhibitor
    $95.00
    Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of...

  • UNC1999 | Methyltransferase inhibitor
    $95.00
    UNC1999 (1431612-23-5) is an orally bioavailable, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50's = 45 nM and 2 nM respectively).1 Inhibition of EZH2 with UNC1999...

  • Zebularine | DNA methylation inhibitor
    $50.00
    Zebularine (3690-10-6) is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Zebularine inhibits cytidine...

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