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Metabolism

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  • 2-Deoxy-D-Glucose | Biologically active glucose analog
    $20.00
    2-Deoxy-D-glucose (154-17-6) is a synthetic glucose analog with extensive biological effects. It is commonly thought of as an inhibitor of glycolysis, but its metabolic effects are wide-ranging. 2-Deoxy-D-glucose...

  • 3PO | 6-Phosphosfructo-2-kinase (PFKFB3) inhibitor
    $45.00
    3PO (18550-98-6) is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3).  PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic...

  • 680C91 | 163239-22-3 | Structure | Supplier
    $68.00
    680C91 (163239-22-3) is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM).1,2 Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake...

  • AGI-5198 | R132 mutant isocitrate dehydrogenase inhibitor
    $70.00
    AGI-5198 (135526-35-0) is a potent (IC50 = 70 nM) inhibitor of mutant isocitrate dehydrogenase 1(IDH1).1  It is selective for the R132H-IDH1 mutant and does not affect wild type cells.2  This mutation results in...

  • Arecoline HBr | ACAT1 inhibitor
    $30.00
    Arecoline (300-8-3) is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA...

  • Atglistatin | ATGL inhibitor
    $60.00
    Atglistatin (1469924-27-3) is the first small molecule inhibitor of adipose triglyceride lipase (ATGL) – IC50 = 700 nM.1  It exhibits high selectivity for ATGL, is active in vitro and in vivo, and does not inhibit...

  • BI-6015 | 93987-29-2 | Structure | Supplier
    $48.00
    BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to...

  • BML283 | PKM2 activator
    $45.00
    BML283 (562867-96-3) is a selective activator of the Tumor Specific M2 Isoform of Pyruvate Kinase (PKM2) - AC50 = 111nM.1 PKM2 activity is downregulated in most cancer cells leading to a decrease in catabolic metabolism and...

  • CB-839 | Glutaminase inhibitor
    $90.00
    CB-839 (14393999-58-2) is a potent (IC50 = 24 nM), selective and orally bioavailable inhibitor of glutaminase (KGA and GAC).1 CB-839 displayed an antiproliferative effect in the triple-negative breast cancer cell line,...

  • CBR-5884 |681159-27-3 | Structure | Supplier
    $70.00
    CBR-5884 (681159-27-3) is a potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM1. The action of PHGDH is the first committed step of serine biosynthesis2 and certain cancer cells...

  • Cerulenin | Fatty Acid Synthase inhibitor
    $90.00
    Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM.1 Cerulenin produces...

  • CHS-828 | NAMPT inhibitor
    $50.00
    CHS-828 (200484-11-3) is a potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the biosynthesis of NAD, which may be used to deplete cells of NAD.1 Displays potent...

  • CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase
    $125.00
    CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol with decreasing levels of...

  • Enasidenib | Inhibitor of IDH2
    $55.00
    Enasidenib (1446502-114-9) is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2)...

  • Eniluracil | Dihydropyrimidine dehydrogenase inhibitor
    $40.00
    Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1,2,3  DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU). ...

  • FK-866 HC; | 658084-64-1 (free base) | Structure | Supplier
    $90.00
    FK866 HCl (658084-64-1 base) is a nicotinamide phosphoribosyltransferase inhibitor (Ki=0.4 nM). Induces tumor cell apoptosis. FK-866 HCl extends lifespan of human cells. Cell permeable. References/Citations 1) Hasmann et...

  • Geldanamycin-FITC | Structure | Supplier
    $200.00
    Geldanamycin-FITC is a novel geldanamycin fluorescent probe1 that may be used in a fluorescence polarization assay for HSP-90 inhibitors.2,3 May also be used for detection of cell surface HSP-90 and for other applications...

  • Gimeracil | Dihydropyrimidine dehydrogenase inhibitor
    $50.00
    Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.  DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).  Gimeracil is used along...

  • IntelliScreen Cellular Metabolism Library 3 plates 100 ul/well
    $5,250.00
    Concentrations vary based on effective concentrations - see library compound list.

  • Koningic acid | Glyceraldehyde-3-phosphate dehydrogenase inhibitor
    $200.00
    Koningic acid (KA; 74310-84-2) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).1  Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the...

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