Modify Search
Select all
Products
Pages
Posts
Modify Search
Select all
Products
Pages
Posts
PhysioProcesses

Programmed Cell Death

Cell death can be divided in two major categories. Necrosis results from cellular injury caused by external factors such as trauma or infection. Programmed cell death is a regulated process that is mediated by various intracellular programs. Types of programmed cell death include apoptosis, anoikis, necroptosis, ferroptosis, pyroptosis, and parthanatos. These types of programmed cell death other than apoptosis have also been termed stress-induced cell death (SCID).

Anoikis

Anisomycin | Anoikis sensitizer

CAS:
22862-76-6
Catalog Number:
10-2056
Activity:
Anoikis sensitizer
Chemical Name:
(2R,3S,4S)-4-Hydroxy-2-)4-methoxybenzyl)pyrrolidin-3-yl acetate
Molecular Weight:
265.31
Molecular Formula:
C14H19NO4
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Apoptosis

P053 | Protein phosphatase 5 inhibitor

P053 (1022417-69-1) is a selective inhibitor of protein phosphatase 5 (PP5) – IC50 = 706 nM.1  PP5 regulates signaling cascades that are responsible for tumor initiation,

Z-DEVD-FMK | Caspase-3 inhibitor

CAS:
210344-95-9
Catalog Number:
10-2904
Activity:
Caspase-3 inhibitor
Chemical Names:
Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Molecular Weight:
668.67
Molecular Formula:
C30H41FN4O12
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Lyophilized solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Ferroptosis

Altretamine | Ferroptosis inducer

CAS:
645-05-6
Catalog Number:
10-5592
Activity:
Ferroptosis inducer/GPX4 inhibitor
Chemical Names:
N2,N2,N4,N4,N6,N6-Hexamethyl-1,3,5-triazine-2,4,6-triamine; 2,4,6-Tris(dimethylamino)-1,3,5-triazine
Alternate Name:
Hexamethylmelamine; NSC-13875
Molecular Weight:
210.29
Molecular Formula:
C9H18N6
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Necroptosis

CBL0137 | Inhibitor of the histone chaperone FACT

CBL0137 (1197996-80-7) is an anticancer agent that activates p53 and suppresses NF-kB via trapping of the FACT (facilitates chromatin transcription) complex, an important histone chaperone that mediates nucleosome

Necrosulfonamide | Necroptosis inhibitor / MLKL inhibitor

CAS:
1360614-48-7
Catalog Number:
10-4860
Activity:
Necroptosis inhibitor / MLKL inhibitor
Chemical Name:
(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
Molecular Weight:
461.47
Molecular Formula:
C18H15N5O6S2
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

GSK872 | Necroptosis inhibitor / RIP3 inhibitor

CAS:
1346546-69-7
Catalog Number:
10-4861
Activity:
Necroptosis inhibitor / RIP3 inhibitor
Chemical Name:
N-(6-Propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine
Alternate Names:
GSK2399872A
Molecular Weight:
383.49
Molecular Formula:
C19H17N3O2S2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Off-White or pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Paraptosis

Ophiobolin A | Autophagy inducer / Anticancer

CAS:
4611-05-6
Catalog Number:
10-3150
Activity:
Autophagy inducer / Anticancer
Alternate Names:
Cochliobolin A; Ophiobalin; NSC 114340
Molecular Weight:
400.55
Molecular Formula:
C25H36O4
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Pyroptosis

1G244 | DPP8/9 inhibitor

CAS:
847928-32-9
Catalog Number:
10-4584
Activity:
DPP8/9 inhibitor
Chemical Names:
(S)-2-Amino-4-{4-[bis-(4-fluorophenyl)-methyl]piperazin-1-yl}-1-(1,3-dihydro-isoindol-2-yl)-butane-1,4-dione
Alternate Name:
PTX-1210
Molecular Weight:
504.57
Molecular Formula:
C29H30F2N4O2
Solubility:
Soluble in DMSO (>20 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Belnacasan | ICE/caspase-1 inhibitor

CAS:
273404-37-8
Catalog Number:
10-4399
Activity:
ICE/caspase-1 inhibitor
Chemical Names:
(S)-1-((S)-2-(4-Amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide; VX-765
Molecular Weight:
508.99
Molecular Formula:
C24H33ClN4O6
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white to white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Talabostat mesylate | Pyroptosis inducer / Inflammasome activator

CAS:
150080-09-4
Catalog Number:
10-4005
Activity:
Pyroptosis inducer / Inflammasome activator
Chemical Name:
((2R)-1-((2S)-2-Amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid methanesulfonate
Alternate Names:
Val-boroPro; PT-100
Molecular Weight:
310.18
Molecular Formula:
C9H19BN2O3 • CH3SO3H
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
97% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Other Programmed Cell Death

Elesclomol | Copper chelator/Cuproptosis inducer

Elesclomol (488832-69-5) induced oxidative stress in cancer cells via rapid generation of reactive oxygen species.1 It preferentially binds copper ions outside the cell and selectively transports inside the mitochondria

Z-DEVD-FMK | Caspase-3 inhibitor

CAS:
210344-95-9
Catalog Number:
10-2904
Activity:
Caspase-3 inhibitor
Chemical Names:
Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Molecular Weight:
668.67
Molecular Formula:
C30H41FN4O12
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Lyophilized solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

BAY-876 | GLUT1 inhibitor

CAS:
1799753-84-6
Catalog Number:
10-4708
Activity:
GLUT1 inhibitor
Chemical Names:
N4-[1-(4-Cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide
Molecular Weight:
496.43
Molecular Formula:
C24H16F4N6O2
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT