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Ubiquitin Proteasome

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  • Aclacinomycin A | 57576-44-0 | Structure | Supplier
    $75.00
    Aclacinomycin A HCl (75443-99-1) is a specific inhibitor of the 20S proteasome chymotrypsin-like activity.1 Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 μM in ILU-18 cells ) the removal of...

  • b-AP15 | 1009817-63-3 | Structure | Supplier
    $60.00
    b-AP15 (1009817-63-3) abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of...

  • Bortezomib | Proteasome inhibitor
    $50.00
    Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM).  Inhibits TNFα synthesis and FGF-induced angiogenesis. Clinically useful agent for...

  • Carfilzomib | 868540-17-4 | Structure | supplier
    $50.00
    Carfilzomib (868540-17-4) is a potent and irreversible proteasome inhibitor.1 Synthetic analog of the microbial product epoxomcin.2 Compared to bortezomib it displays equal potency but greater selectivity for the...

  • Celastrol | Proteasome inhibitor
    $116.00
    Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM).  It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin...

  • Epoxomicin | 134381-21-8 | Structure | Supplier
    $145.00
    Epoxomicin (134381-21-8) is a potent, selective and cell permeable irreversible inhibitor of the 20S proteasome.1 It does not inhibit non-proteasomal proteases such as papain, chymotrypsin, trypsin, calpain and cathepsin B...

  • Lenalidomide | Immunomodulator
    $50.00
    Lenalidomide (191732-72-6) is a thalidomide analog which, like thalidomide1, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2...

  • MDBN | 1485-00-3 | Structure | Supplier
    $40.00
    MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable References/Citations1) Chou et al. (2011), Quantitative cell-based protein degradation assays to identify and classify drugs that...

  • MLN4924 | 905579-51-3 | Structure | Supplier
    $40.00
    MLN4924 (905579-51-3) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor. Disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Supresses the growth of tumor...

  • NSC-697923 | 343351-67-7 | Structure | Supplier
    $50.00
    NSC-69723 (343351-67-7) is a selective inhibitor of E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B...

  • P5091 | 882257-11-6 | Structure | Supplier
    $60.00
    P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM)1,2. Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance1. P5091 displays antiangiogenic...

  • Piperlongumine | Glutathione sponge / Increases ROS levels
    $80.00
    Piperlongumine (20069-09-4) elevates cellular levels of reactive oxygen species selectively in cancer cell lines1. Irreversible glutathionylation leading to depletion of cellular glutathione is associated with its cellular...

  • PR-619 | 2645-32-1 | Structure | Supplier
    $48.00
    PR-619 (2645-32-1) is a nonselective, reversible inhibitor of cysteine-reactive deubiquitinating enzymes (DUBs; 5-20 μM)1. PR-619 is highly useful for preserving ubiquitinated proteins during cell lysis. DUBs become...

  • Pyr41 | 418805-02-4 | Structure | Supplier
    $50.00
    Pyr41 (418805-02-4) inhibits ubiquitin activating enzyme E1 (>60% inhibition at 10 μM) with little or no activity against E2 or E3. Cell permeable References/Citations1) Yang et al. (2007), Inhibitors of...

  • Spautin-1 | 1262888-28-7 | Structure | Supplier
    $70.00
    Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1...

  • Thalidomide | 50-35-1 | Structure | Supplier
    $50.00
    Thalidomide (50-35-1) binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution,...

  • WP-1130 | 856243-80-6 | Structure | Supplier
    $60.00
    WP-1130 (856243-80-6) is a novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Triggers tumor cell apoptosis.1 Blocks Jak2 signaling via Jak2...

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