my account
Login
  Loading... Please wait...

Atherosclerosis

Sort by
  • 5alpha,6alpha-Epoxycholesterol | LXR ligand
    $25.00
    5α,6α-Epoxycholesterol (1250-95-9) is a naturally occurring metabolite of cholesterol.  It is a major oxysterol found in processed food1 and has been implicated in atherosclerosis2,3...

  • Isradipine | 75695-93-1 | Structure | Supplier
    $64.00
    Isradipine (75695-93-1) is an L-type calcium channel blocker. Displays antiatherosclerotic effects and improves endothelium-mediated nitric oxide-dependent vasodilation. Isradipine displays neuroprotective activity in rat...

  • Leonurine | Neuroinflammation inhibitor
    $48.00
    Inhibits microglial overactivation and attenuates Aβ(1-40)-induced cognitive impairments in rats via JNK and NF-κB pathways.1 Inhibits the formation of advanced glycation end products.2 Ameliorates cognitive...

  • Lovastatin | 75330-75-5 | Structure | Supplier
    $41.00
    Lovastatin (75330-75-5) Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase (Ki=1nM for acid form).1,2 Induces apoptosis in various cell lines.3 Causes cell cycle arrest in early G1 phase.4...

  • Manzamine A | Inhibitor of vacuolar ATPases
    $185.00
    Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis in vivo2. Manzamine A displays neuritogenic activity3 and suppresses tau...

  • RVX-208 | 1044870-39-4 | Structure | Supplier
    $68.00
    RVX-208 (1044870-39-4) is a potent BET bromodomain antagonist with IC50 of 0.510 μM for BD2, with approximately 170-fold selectivity over BD11,2. RVX-208 increases apolipoprotein A-1 and HDL cholesterol in vitro and in...

  • SR-9009 | RevErb alpha & beta agonist
    $78.00
    SR-9009 (1379686-30-2) is an agonist at nuclear receptor Rev-ErbA1. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model2. SR-9009 suppresses...

  • TMP-153 | ACAT inhibitor
    $36.00
    TMP-153 (128831-46-9) is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), IC50=5-10 nM. It inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.1,2 TMP-153...

  • Triacsin C | Acyl-CoA synthase inhibitor
    $90.00
    Triacsin C (76896-80-5) is a long-chain fatty acyl CoA synthetase inhibitor (IC50=3.6-8.7 μM)1. Inhibits mouse macrophage-derived foam cell formation2 and displays anti-atherosclerotic activity3. Cell permeable...

Share Focus

Connect with Focus