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Hypertension

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  • Amlodipine | 88150-42-9 | Structure | Supplier
    $59.00
    Amlodipine (88150-42-9) is an anti-hypertensive L-type calcium channel blocker, which also benefits the cardiovascular system by stimulating nitric oxide synthase, inhibiting angiotension-induced oxidative stress and...

  • Captopril | Angiotensin-converting enzyme inhibitor
    $30.00
    Captopril (62571-86-2) is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM).1 Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and...

  • Diazoxide | K-ATP channel activator
    $40.00
    Activates ATP-dependent K+ channels1 via inducing translocation of PKC-epsilon from the cytosol to the mitochondria2. Hyperglycemic agent. Induces powerful protective effects against cardiac ischemia via multiple mechanisms...

  • Diltiazem HCl | 33286-22-5 | Structure | Supplier
    $30.00
    Diltiazem HCl (33286-22-5) is a non-dihydropyridine-type blocker of L-type Ca2+ channels1,2.Reduces Ca2+ oscillations in subcellular compartments in vascular smooth muscle cells3. Also blocks P-type Ca2+ channels in...

  • Felodipine | L-type Ca channel blocker
    $56.00
    Felodipine (72509-76-3) is a potent L-type Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels.1,2 It displays high vascular selectivity over cardiac muscle, thus lowering arterial blood pressure...

  • Isradipine | 75695-93-1 | Structure | Supplier
    $64.00
    Isradipine (75695-93-1) is an L-type calcium channel blocker. Displays antiatherosclerotic effects and improves endothelium-mediated nitric oxide-dependent vasodilation. Isradipine displays neuroprotective activity in rat...

  • Losartan potassium | Angiotensin AT1 antagonist
    $40.00
    Losartan potassium (124750-99-8) is a non-peptide angiotensin II receptor antagonist.1,2 Clinically useful antihypertensive agent.3 Inhibits collagen I synthesis.4 Induces SIRT1 expression and activity and...

  • Minoxidil | 38304-91-5 | Structure | Supplier
    $56.00
    Minoxidil (38304-91-5) is a direct antihypertensive peripheral vasodilator acting via activation of KATP channels leading to relaxation of smooth muscle.1 Active metabolite is minoxidil sulfate (IC50 = 0.14 μM). Minoxidil...

  • Nicardipine HCl | L-type Ca channel blocker / MDR inhibitor
    $45.00
    Nicardipine (54527-84-3) is a clinically useful L-type calcium blocker. Inhibitor of MDR.2 References/Citations1) Merck 14 6495 2) Hulubei et al. (2012), 4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the...

  • Nifedipine | 21829-25-4 | Structure | Supplier
    $40.00
    Nifedipine (21829-25-4) is a clinically useful L-type calcium blocker. References/Citations1) Vater et al., (1972), (Pharmacology of 4-(2'-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester...

  • Nilvadipine | Syk inhibitor and Calcium channel blocker
    $70.00
    Nilvadipine (75530-68-6) is a novel DHP L-type Ca2+ channel blocker that also inhibits Syk.1 Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro...

  • Nitrendipine | L-type Ca channel blocker
    $80.00
    Nitrendipine (39562-70-4) is a clinically useful L-type calcium blocker. References/Citations1) Meyer et al., (1981), (Synthesis and comparative pharmacological studies of...

  • Phenoxybenzamine HCl | 63-92-3 | Structure | Supplier
    $30.00
    Phenoxybenzamine HCl (63-92-3) binds to and inhibits calmodulin in a calcium-dependent and irreversible manner (IC50= ca. 1 μM)1. A classical irreversible α adrenergic antagonist2. Phenoxybenzamine HCl is a useful...

  • Reparixin | CXCR 1/2 allosteric antagonist
    $52.00
    Reparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors (IC50 = 1 and 100 nM, respectively). It blocks a number of activities related to IL-8 signaling, including...

  • Ro 13-6438 | Quazinone | 70018-51-8 | Structure | Supplier
    $75.00
    Ro 13-6438 (70018-51-8) is a selective inhibitor of phosphodiesterase III (PDE III, IC50 = 0.6 μM). References/Citations1) Eigenmann et al. (1984) Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent...

  • Terazocin HCl | Adrenergic antagonist
    $50.00
    Terazocin HCl (63074-08-8) is an α1- and α2B-adrenoceptor antagonist (Ki = 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α1A, α1B, α1D, α2B, α2A and α2C receptors respectively)1...

  • Valsartan | Angiotensin antagonist
    $50.00
    Valsartan (137862-53-4) is a high affinity angiotensin AT1 receptor antagonist (Ki = 2.38 nM). Highly selective (30,000-fold) over AT2 receptors1,2. Normalizes the increased production of inflammatory cytokines in adipose...

  • Verapamil HCl | 152-11-4 | Structure | Supplier
    $27.00
    Verapamil HCl (152-11-4) is a clinically useful L-type calcium channel blocker.1 It is also used as an inhibitor of drug efflux pump proteins.2 References/Citations1) Brgden and Benfield (1996) Verapamil: a review of its...

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