MitoBloCK-10 | TIMM44 blocker
MitoBloCK-10 (394694-98-5) is a first in class TIMM44 blocker. Translocase of inner mitochondrial membrane 44 (TIMM44) is essential for maintaining function and integrity of mitochondria.1 It
Complex Carbohydrates
EV-96 | Cysteine-reactive T cell activation suppressor
EV-96 is a cysteine-reactive immunosuppressive agent that suppresses T cell activation (EC50 <2.5 µM) via inhibition of NF-kB activation and degradation of key immune-relevant proteins including
E7820 | RBM39 molecular glue
E7820 (289483-69-8) is an angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ß1.1 Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin
EN450 | NFkB1 molecular glue
EN450 (793719-01-4) is a molecular glue that covalently interacts with a cysteine residue on the E2 ubiquitin ligase UBE2D. It displayed anti-proliferative effects in HAP1 leukemia
SJ6986 | GSPT1 molecular glue
SJ6986 (2765625-93-0) is a potent (IC50 = 15 nM for Cereblon; EC50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glue degrader
