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Complex Carbohydrates

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  • Castanospermine | 79831-76-8 | Structure | Supplier
    Castanospermine (79831-76-8) is a natural product, derived from Castanospermum austral. Potent inhibitor of α- and β-glucosidases. Exhibits antiviral properties. Inhibits HIV infectivity. Inhibits thyroglobulin...

  • Conduritol B epoxide | 6090-95-5 | Structure | Supplier
    Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.1,2 May be used for generation of the “Gaucher mouse”3 and the in vitro model of the Gaucher cell4. References/Citations 1) Datta and Radin...

  • Deoxymannojirimycin HCl | Mannosidase inhibitor
    Potent and selective inhibitor of α-mannosidase I.1,2 Inhibits the conversion of high mannose to complex oligosaccharides.3 Attenuates tunicamycin-, thapsigargin- and Aβ1-42-induced ER stress dependent neuronal...

  • Deoxynojirimycin | Glucosidase inhibitor
    Deoxynojirimycin (19130-96-2) inhibits α-glucosidase I and II1,2. Inhibits human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step3. May be used to produce an affinity...

  • Isofagomine tartrate | Glucocerebrosidase activator and chaperone
    Isofagomine tartrate (957230-65-8) is a competitive inhibitor of human lysosomal β-glucosidase, IC50 = 0.06 μM.1 Increases the activity of N370S mutant acid β-glucosidase (GlcCerase) in Gaucher fibroblasts.2...

  • Kifunensine | Mannosidase inhibitor
    Historically isolated from Kitasato kifunensine.1 Inhibitor of class I α-mannosidases which inhibit glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases...

  • Miglitol | beta-glucosidase inhibitor / antidiabetic
    Miglitol (72432-03-2) is an α-glucosidase inhibitor which induces an enhanced and prolonged release of glucagon-like peptide-1, regulating appetite and stabilizing body weight in humans1. Miglitol displays...

  • Miglustat HCl | Alpha-glucosidase inhibitor
    Miglustat HCl (210110-90-0) is an orally active ceramide-specific glycosyltransferase and α-glucosidase I and II inhibitor.1 Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of...

  • Swainsonine | Glycosidase inhibitor
    Swainsonine (72741-87-8) is a naturally occurring alkaloidal toxin found in locoweed. Inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II (IC50 = 0.2 mM).1 Inhibits growth and potentiates...

  • Thiamet G | O-GlcNAcase alpha 1 antagonist
    Thiamet G (1009816-48-1) is a potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Increases levels of O-GlcNAc-modified proteins in cellular assays and in vivo. Suppresses phosphorylation of tau...

  • Tunicamycin | ER stress inducer
    Tunicamycin (11089-65-9) is a fermentation product from Streptomyces lysosuperificus.  Provided as a mixture of tunicamycin A (C14), B (C15), C (C16) and D (C17) homologs varying in the number of carbon atoms in the...

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