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Lipid metabolism and signaling

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  • Cerulenin | Fatty Acid Synthase inhibitor
    $90.00
    Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM.1 Cerulenin produces...

  • CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase
    $125.00
    CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol with decreasing levels of...

  • DU-14 | 186303-55-9 | Structure | supplier
    $72.00
    DU-14 (186303-55-9) inhibits steroid sulfatase (IC50=ca. 60 nM). Enhances learning and spatial memory in rats1. Inhibits proliferation of human MCF-7 breast cancer cells2. References/Citations1) Johnson et al. (2000), The...

  • FSG67 | GPAT inhibitor
    $55.00
    FSG67 (1158383-34-6) is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM.1 It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid...

  • GE-501516 | PPAR delta agonist
    $68.00
    GW-501516 (317318-70-0) is a potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes.1  Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves...

  • IPBT-5CA | 306935-41-1 | Structure | Supplier
    $70.00
    IPBT-5CA (306935-41-1) is a highly selective agonist for the human orphan G-protein-coupled receptor GPR109b (EC50 = 400 nM). No activity was reported at the highly homologous high-affinity niacin receptor GPR109a...

  • JNJ-1661010 | 681136-29-8 | Structure | Supplier
    $100.00
    JNJ-1661010 (681136-29-8) is a potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in...

  • JZL-184 | 1101854-58-3 | Structure | Supplier
    $62.00
    JZL-184 (1101854-58-3) inhibits MAG lipase (IC50=8 nM) selectively over FAAH. Irreversible. Cell permeable. References/Citations1) Long et al. (2009), Selective blockade of 2-arachidonoylglycerol hydrolysis produces...

  • LY-2183240 | Anandamide uptake inhibitor
    $60.00
    LY-2183240 (874902-19-9) is highly potent inhibitor of cellular anandamide uptake (IC50 = 0.27nM1, 15nM2). LY-2183240 has also been found2,3,4 to be an inhibitor of fatty acid amide hydrolase (FAAH) - IC50 = 14nM4,...

  • MF-438 | SCD1 inhibitor
    $60.00
    MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg).1 Cancer initiating cells (CSC-like) were shown...

  • Orlistat | DAG Lipase-alpha inhibitor
    $30.00
    Orlistat (96829-58-2) is a lipase inhibitor which blocks the biosynthesis of 2-AG by inhibition of DAG lipase-α1. Inhibits pancreatic lipase and other lipases but not PLA22. Inhibits fatty acid synthase and displays...

  • PF-622 | 898235-63-9 | Structure | Supplier
    $80.00
    PF-622 (898235-65-9) is a potent and selective irreversible FAAH inhibitor. Covalently modifies active site-serine (IC50=33 nM). Completely selective for FAAH relative to other mammalian serine hydrolases. Cell...

  • PluriSln#1 | Stearoyl CoA desaturase inhibitor
    $50.00
    PluriSln#1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln#1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated...

  • RHC-80267 | DAG Lipase inhibitor
    $55.00
    RHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic...

  • SR-144528 | 192703-06-3 | Structure | Supplier
    $100.00
    SR-144528 (192703-06-3) is a potent and selective antagonist of the cannabinoid CB2 receptor1,2. References/Citations1) Rinaldi-Carmona et al. (1998), SR-144528, the first potent and selective antagonist of the CB2...

  • SR9243 | LXR inverse agonist
    $45.00
    SR9243 (1613028-81-1) is an LXR inverse agonist that significantly inhibits the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression.1 Induces apoptosis in a variety of cancer cell types...

  • TMP-153 | ACAT inhibitor
    $36.00
    TMP-153 (128831-46-9) is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), IC50=5-10 nM. It inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.1,2 TMP-153...

  • TOFA | 54857-86-2 | Structure | Supplier
    $50.00
    TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1)1. Induces apoptosis in a variety of tumor cell lines2,3. Stimulates neurite outgrowth and neuronal differentiation in rat...

  • Triacsin C | Acyl-CoA synthase inhibitor
    $90.00
    Triacsin C (76896-80-5) is a long-chain fatty acyl CoA synthetase inhibitor (IC50=3.6-8.7 μM)1. Inhibits mouse macrophage-derived foam cell formation2 and displays anti-atherosclerotic activity3. Cell permeable...

  • URB-597 | 546141-08-6 | Structure | Supplier
    $35.00
    URB-597 (546141-08-6) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, IC50 = 3-5 nM.1 Produces cannabinoid CB1 and CB2 receptor-mediated analgesia in inflammatory pain states without causing side...

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