Vacuolin-1 | Autophagy/PIKfyve inhibitor
Vacuolin-1 (351986-85-1) inhibits autophagy via inhibition of Ca2+-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content and has no effect on
Cellular Stress
Cellular responses to stress are important for cell survival and maintaining genomic stability. Signaling pathways and other systems activated in cellular stress include heat shock, ubiquitin-proteasome, DNA damage response, inflammasome, unfolded protein response, NFκB, ERK/JNK/p38 MAPK, and Keap1-Nrf2 among others. While these responses may be beneficial for normal cells, they can be co-opted in pathological states such as cancer to the detriment of the organism.
Autophagy
AR7 | Activates chaperone mediated autophagy
CAS:
80306-38-3
Catalog Number:
10-5515
Activity:
Activates chaperone mediated autophagy
Chemical Names:
7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
Molecular Weight:
257.72
Molecular Formula:
C15H12ClNO
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Pale pink solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
R-59022 | DAG kinase inhibitor
CAS:
93076-89-2
Catalog Number:
10-3579
Activity:
SGLT2 inhibitor
Chemical Names:
6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
Molecular Weight:
459.58
Molecular Formula:
C27H26FN3OS
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
DNA Damage Response
TH10785 | OGG1 activator
TH10785 (1002801-51-5) is an 8-oxo guanine DNA glycosylase 1 (OGG1) activator. Oxidative DNA damage is recognized by OGG1 which then excises 8-oxoguanine, leaving a substrate for
VE-821 | Potent and selective ATR inhibitor
CAS:
1232410-49-9
Catalog Number:
10-5589
Activity:
ATR inhibitor
Chemical Names:
3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
Molecular Weight:
368.41
Molecular Formula:
C18H16N4O3S
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Beige solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
SU0268 | OGG1 inhibitor
CAS:
2210228-45-6
Catalog Number:
10-4700
Activity:
OGG1 Inhibitor
Chemical Names:
3-[4-[[1-(Cyclopropanecarbonyl)-3,4-dihydro-2H-quinolin-7-yl]sulfamoyl]phenyl]benzamide
Molecular Weight:
475.56
Molecular Formula:
C26H25N3O4S
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
ER Stress
C-DIM 8 | Nur77 Antagonist
CAS:
151358-47-3
Catalog Number:
10-5157
Activity:
Nur77 antagonist
Chemical Names:
1,1-Bis(3’-indolyl)-1-(p-hydroxyphenyl)methane
Alternate Name:
DIM-C-pPhOH
Molecular Weight:
338.41
Molecular Formula:
C23H18N2O
Solubility:
Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
Physical Properties:
Pink solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Ceapin-A7 | ATF6α/UPR inhibitor
CAS:
2323027-38-7
Catalog Number:
10-3974
Activity:
ATF6α/UPR inhibitor
Chemical Names:
N-(1-{[2,4-bis(Trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-5-(furan-2-yl)-1,2-oxazole-3-carboxamide
Molecular Weight:
470.33
Molecular Formula:
C20H12F6N4O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
AA147 | ATF6 activator
CAS:
393121-74-9
Catalog Number:
10-3973
Activity:
Activator of ER stress sensing protein ATF6
Chemical Names:
N-(2-Hydroxy-5-methylphenyl)-3-phenylpropanamide; Compound 147
Molecular Weight:
255.32
Molecular Formula:
C16H17NO2
Solubility:
Soluble in DMSO (>25 mg/ml); ethanol (>25 mg/mL)
Physical Properties:
Beige to pale orange solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
HSP
BGP-15 | Cellular protectant
CAS:
66611-37-8
Catalog Number:
10-1373
Activity:
Cellular protectant
Chemical Names:
N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
Molecular Weight:
351.28
Molecular Formula:
C14H22N4O2·2HCl
Solubility:
Soluble in Water (70 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
Shipping Code:
RT
KNK437 | HSP70 inhibitor
CAS:
218924-25-5
Catalog Number:
10-5561
Activity:
HSP70 inhibitor
Chemical Names:
3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
Molecular Weight:
245.23
Molecular Formula:
C13H11NO4
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
BIIB021 | HSP90 Inhibitor
CAS:
848695-25-0
Catalog Number:
10-4641
Activity:
Potent HSP90 inhibitor
Chemical Names:
6-Chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]purin-2-amine; CNF2024
Molecular Weight:
318.76
Molecular Formula:
C14H15ClN6O
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha.
Shipping Code:
RT
Hypoxia
Roxadustat | Proyl hydroxylase domain inhibitor / HIF stabilizer
CAS:
808118-40-3
Catalog Number:
10-4468
Activity:
Proyl hydroxylase domain inhibitor / HIF stabilizer
Chemical Name:
2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
Alternate Name:
FG-4592
Molecular Weight:
352.35
Molecular Formula:
C19H16N2O5
Solubility:
Soluble in DMSO (up to at least 25 mg/ml).
Physical Properties:
Off-white or white solid
Purity:
99% by HPLC
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
YC-1 | Soluble guanylyl cyclase activator
CAS:
170632-47-0
Catalog Number:
10-1581
Activity:
Soluble guanylyl cyclase activator
Chemical Name:
3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole
Alternate Name:
Lificiguat
Molecular Weight:
304.34
Molecular Formula:
C19H16N2O2
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Pink solid
Purity:
98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
BAY 87-2243 | HIF-1 / Mitochondrial complex I inhibitor
CAS:
1227158-85-1
Catalog Number:
10-4910
Activity:
HIF-1 / Mitochondrial complex I inhibitor
Chemical Name:
5-[1-[[2-(4-Cyclopropylpiperazin-1-yl)pyridin-4-yl]methyl]-5-methylpyrazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
Molecular Weight:
525.54
Molecular Formula:
C26H26F3N7O2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Oxidative Stress
N-Acetylcysteine ethyl ester | Cell permeable antioxidant
N-Acetylcysteine ethyl ester (59587-09-6) is a lipophilic, cell permeable ethyl ester derivative of N-acetylcysteine.1 In oxidative stressed retinal pigment epithelial (RPE) cells NACET increases viability more
Lipoic acid | Endogenous antioxidant and cofactor
alpha-Lipoic acid (1077-28-7) is an endogenous antioxidant.1,2 Treatment with alpha-lipoic acid increased hepatic nuclear Nrf2 levels, induced Nrf2-mediated gene transcription, and reversed age-related decline in hepatic
HET0016 | 20-HETE biosynthesis inhibitor
HET0016 (339068-25-6) inhibits 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis via omega oxidation of arachidonic acid mediated by CYP4A and 4F (IC50=8.9 nM in human renal microsomes).1 It displays
Ubiquitin proteasome
Iberdomide | Cereblon modulator/Molecular glue
Iberdomide (1323403-33-3) is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC50 = 60 nM) than lenalidomide and pomalidomide
CC-90009 | Cereblon modulator/Molecular glue
CC-90009 (1860875-51-9) is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex that specifically targets GSPT1 (G1 to S phase transition 1; EC50
ML-792 | SUMO-activating enzyme inhibitor
ML-792 (1644342-14-2) is a potent (IC50’s = 3 nM SUMO1; 11 nM SUMO2) and selective ( IC50 = 32 µM for NEDD8-activating enzyme (NAE)) mechanism-based inhibitor of
