Cellular trafficking

Cellular trafficking is the transport of proteins, organelles, and other components within a cell, mediated by the ER, Golgi, cytoskeleton, and plasma membrane. It is integral to processes such as secretion, autophagy, immune and neuronal cell function, cancer cell migration, and stem cell differentiation.

Home >> Biochemical Targets >> Cellular trafficking

Endocytosis

PITSTOP2 | Clathrin-mediated endocystosis inhibitor

PITSTOP2 (1332879-52-3) inhibits clathrin-mediated endocytosis via blockade of endocytic ligand association with the clathrin terminal domain leading to clathrin coat assembly inhibition.1 It was able to

Rasarfin | Dual Ras/ARF6 inhibitor

CAS:

674359-73-0

Catalog Number:

10-5498

Activity:

Dual Ras/ARF6 inhibitor

Chemical Names:

N-(3-Chloro-4-(4-isobutyrylpiperazin-1-yl)phenyl)benzofuran-2-carboxamide

Molecular Weight:

425.91

Molecular Formula:

C₂₃H₂₄ClN₃O₃

Solubility:

Soluble in DMSO (70 mg/ml)

Physical Properties:

Yellow solid

Purity:

>98% TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Prochlorperazine maleate | Endocytosis inhibitor

CAS:

84-02-6

Catalog Number:

10-3474

Activity:

Endocytosis inhibitor

Chemical Name:

2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine dimaleate

Molecular Weight:

606.09

Molecular Formula:

C₂₀H₂₄ClN₃S • 2C₄H₄O₄

Solubility:

Soluble in DMSO (up to 15 mg/ml).

Physical Properties:

White solid

Purity:

98% by HPLC

NMR (Conforms)

Storage Temperature:

-20° (des.)

Stability:

Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Shipping Code:

ER/Golgi

Monensin Na | Golgi transport inhibitor

CAS:

22373-78-0

Catalog Number:

10-2659

Activity:

Golgi transport inhibitor

Chemical Names:

2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-hydroxymethyl-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-dioxaspiro[4.5]decane-7-butyric acid, sodium salt

Alternate Name:

NSC-343257

Molecular Weight:

692.86

Molecular Formula:

C₃₆H₆₁O₁₁·Na

Solubility:

Soluble in DMSO (25 mg/ml with warming)

Physical Properties:

White solid

Purity:

90-95% TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

Exo2 | GBF1 inhibitor – induces Golgi disassembly

CAS:

304684-77-3

Catalog Number:

10-1594

Activity:

GBF1 inhibitor – induces Golgi disassembly

Chemical Name:

2-Methoxy-4-[(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol

Molecular Weight:

354.43

Molecular Formula:

C₁₈H₁₈N₄O₂S

Solubility:

Soluble in DMSO (up to 25 mg/ml)

Physical Properties:

Yellow solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase

CAS:

166981-13-1 (free base)

Catalog Number:

10-4560

Activity:

Inhibitor of CTP: choline-phosphate cytidylyltransferase

Chemical Name:

1-(11-Dodecylamino-10-hydroxyundecyl)-3,7-dimethylxanthine methane sulfonate

Molecular Weight:

629.9

Molecular Formula:

C₃₀H₅₅N₅O₃ CH₃SO₃H

Solubility:

Soluble in DMSO (up to 25 mg/ml)

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:

Exocytosis

Endosidin 2 | Exocytosis and endosomal recycling inhibitor

Catalog Number:

10-1583

CAS#:

1839524-44-5

Activity:

Exocytosis and endosomal recycling inhibitor

Chemical Name:

(E)-3-Fluoro-N’-(4-hydroxy-3-iodo-5-methoxybenzylidene)benzohydrazide

Molecular Weight:

414.17

Molecular Formula:

C₁₅H₁₂FIN₂O₃

Solubility:

Soluble in DMSO (greater than 40 mg/ml), in DMF (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20°C for up to 1 month.

Shipping Code:

Nuclear export

BTB-1 | Mitotic kinesin Kif18A inhibitor

CAS:

86030-08-2

Catalog Number:

10-1543

Activity:

Mitotic kinesin Kif18A inhibitor

Chemical Names:

4-Chloro-2-nitro-1-(phenylsulfonyl)benzene; NSC 156750

Molecular Weight:

297.71

Molecular Formula:

C₁₂H₈ClNO₄S

Solubility:

Soluble in DMSO (30 mg/ml)

Physical Properties:

White to off-white solid

Purity:

98% HPLC
NMR (Conforms)

Storage Temperature:

Room temperature

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:

Selinexor | Inhibitor of the nuclear export receptor CRM1/XPO1

CAS:

1393477-72-9

Catalog Number:

10-4011

Activity:

Inhibitor of the nuclear export receptor CRM1/XPO1

Chemical Name:

(Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N’-pyrazin-2-ylprop-2-enehydrazide

Alternate Name:

KPT-330

Molecular Weight:

443.31

Molecular Formula:

C₁₇H₁₁F₆N₇O

Solubility:

Soluble in DMSO (up to at least 25 mg/ml). or in Ethanol (up to at least 25 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Shipping Code:

Leptomycin B | Nuclear export inhibitor

CAS:

87081-35-4

Catalog Number:

10-2084

Activity:

Nuclear export inhibitor

Molecular Weight:

540.75

Molecular Formula:

C₃₃H₄₈O₆

Solubility:

Supplied in solution in ethanol (1 mg/ml). Further dilutions may be made with either ethanol or DMSO.

Physical Properties:

Solution in ethanol (1mg/ml)

Purity:

99% by HPLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 1 year from date of purchase as supplied. Solutions or dilutions in DMSO are not stable. Solutions should be made fresh and used within one working day.

Shipping Code:

Nuclear import

Ivermectin | Nuclear transport inhibitor

CAS:

70288-86-7

Catalog Number:

10-2628

Activity:

Nuclear transport inhibitor

Chemical Name:

22,23-Dihydroavermectin B1

Alternate Name:

22,23-Dihydro C076B1; MK-933

Molecular Weight:

875.09

Molecular Formula:

C₄₈H₇₄O₁₄ (B1a form)

Solubility:

Soluble in DMSO (up to 70 mg/ml) or in Ethanol (up to 25 mg/ml).

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)
Contains up to 10% B1b form

Storage Temperature:

-20°C (des.)

Stability:

Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Shipping Code:

Importazole | Blocks importin-ß-mediated nuclear import

CAS:

662163-81-7

Catalog Number:

10-1412

Activity:

Blocks importin-β-mediated nuclear import

Alternate Names:

IPZ

Chemical Name:

N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine

Molecular Weight:

318.43

Molecular Formula:

C₂₀H₂₂N₄

Solubility:

Soluble in DMSO (up to 10 mg/ml).

Physical Properties:

Off-white solid

Purity:

97% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Shipping Code:

Catalog Number:

10-3689

Activity:

Endosomal trafficking inhibitor

Chemical Names:

2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide

Molecular Weight:

346.23

Molecular Formula:

C₁₆H₁₆BrN₃O

Solubility:

Soluble in DMSO (50 mg/ml); Ethanol (10 mg/ml with warming)

Physical Properties:

White solid

Purity:

>95% TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:

Cellular trafficking

Endocytosis

PITSTOP2 | Clathrin-mediated endocystosis inhibitor

Rasarfin | Dual Ras/ARF6 inhibitor

Prochlorperazine maleate | Endocytosis inhibitor

ER/Golgi

Monensin Na | Golgi transport inhibitor

Exo2 | GBF1 inhibitor – induces Golgi disassembly

CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase

Exocytosis

Endosidin 2 | Exocytosis and endosomal recycling inhibitor

Nuclear export

BTB-1 | Mitotic kinesin Kif18A inhibitor

Selinexor | Inhibitor of the nuclear export receptor CRM1/XPO1

Leptomycin B | Nuclear export inhibitor

Nuclear import

Ivermectin | Nuclear transport inhibitor

Importazole | Blocks importin-ß-mediated nuclear import

Other

MitoBloCK-10 | TIMM44 blocker

SLB1122168 | Sphingosine-1-phosphate transport inhibitor

EGA | Endosomal trafficking inhibitor

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

Cellular trafficking

Endocytosis

ER/Golgi

Exocytosis

Nuclear export

Nuclear import

Other

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules Plymouth Meeting, PA USA1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21