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BiochemicalTargets

Chaperones

Molecular chaperones are proteins that aid in the folding of newly synthesized polypetide chains and translocation of proteins across membranes. Heat shock proteins such as HSP70 and HSP90 have important roles in proteostasis and protein folding ( and thus function), transportation (and thus location in the cell), and proper degradation. Dysfunctioning chaperones play roles in neurodegeneration, cancer, and autoimmune disease.

Folding enzymes

Cycloheximide-N-ethylethanoate | FKBP12 inhibitor

Catalog Number:
10-1062
Activity:
FKBP12 inhibitor
Chemical Name:
Ethyl 2-(4-((R)-2-((1S, 3S, 5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-2,6-dioxopiperidin-1-yl)acetate
Molecular Weight:
367.44
Molecular Formula:
C19H29NO6
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 3 mg/ml)
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Heat Shock Proteins

Luminespib | HSP90 inhibitor

CAS:
747412-49-3
Catalog Number:
10-4672
Activity:
HSP90 inhibitor
Chemical Names:
5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
Alternate Name:
NVP-AUY922; VER-52296
Molecular Weight:
465.54
Molecular Formula:
C26H31N3O5
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

BGP-15 | Cellular protectant

CAS:
66611-37-8
Catalog Number:
10-1373
Activity:
Cellular protectant
Chemical Names:
N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
Molecular Weight:
351.28
Molecular Formula:
C14H22N4O2·2HCl
Solubility:
Soluble in Water (70 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
Shipping Code:
RT

KNK437 | HSP70 inhibitor

CAS:
218924-25-5
Catalog Number:
10-5561
Activity:
HSP70 inhibitor
Chemical Names:
3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
Molecular Weight:
245.23
Molecular Formula:
C13H11NO4
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Sigma receptor

PB28 dihydrochloride | Potent sigma2 agonist

CAS:
172907-03-8
Catalog Number:
10-4665
Activity:
High affinity sigma2 ligand
Chemical Names:
1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride
Molecular Weight:
443.50
Molecular Formula:
C24H38N2O
Solubility:
Soluble in DMSO (>25 mg/ml) or water (5 mg/ml)
Physical Properties:
White to off-white solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

DTG | High affinity sigma receptor agonist

CAS:
97-39-2
Catalog Number:
10-4204
Activity:
High affinity sigma receptor agonist
Chemical Name:
1,3-Di-o-tolylguanidine
Molecular Weight:
239.32
Molecular Formula:
C15H17N3
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

GBR-12909 2HCl | Dopamine reuptake inhibitor

CAS:
67469-78-7
Catalog Number:
10-1458
Activity:
Dopamine reuptake inhibitor
Chemical Name:
1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Alternate Name:
Vanoxerine
Molecular Weight:
523.5
Molecular Formula:
C28H32F2N2O 2HCl
Solubility:
Soluble in DMSO (up to 30 mg/ml with warming) or in Water (up to 10 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

Small molecule chaperones

YM-58483 | CRAC channel blocker

CAS:
223499-30-7
Catalog Number:
10-2935
Activity:
CRAC channel blocker
Chemical Names:
N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide
Alternate Name:
BTP2
Molecular Weight:
421.32
Molecular Formula:
C15H9F6N5OS
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

QNZ | NFkB inhibitor / Store operated calcium entry

CAS:
545380-34-5
Catalog Number:
10-4009
Activity:
NF-kB inhibitor / Store-operated calcium entry
Chemical Name:
4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine
Alternate Name:
EVP4593
Molecular Weight:
356.42
Molecular Formula:
C22H20N4O
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Other

Honokiol-DCA | TRAP1 Inhibitor

Honokiol-DCA (HDCA; 1620160-42-0), a synthetic bis-dichloroacetate ester of the natural product honokiol, is an allosteric inhibitor of the mitochondrial chaperone TRAP1.1 It binds to an allosteric site

CBL0137 | Inhibitor of the histone chaperone FACT

CBL0137 (1197996-80-7) is an anticancer agent that activates p53 and suppresses NF-kB via trapping of the FACT (facilitates chromatin transcription) complex, an important histone chaperone that mediates nucleosome