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BiochemicalTargets

Cholesterol and Analogues

Cholesterol and its analogues are sterols that function as critical components of the plasma membrane, the basis for bile, and building blocks for steroid hormones and Vitamin D. Because these molecules are necessary for proper functioning of cells and organisms, manipulation of their synthesis, metabolism, and signaling are important areas of cellular signaling research.

Biosynthesis inhibitors

Hymeglusin | Mevalonate biosynthesis inhibitor

CAS:
29066-42-0
Catalog Number:
10-3289
Activity:
Melvalonate biosynthesis inhibitor
Chemical Name:
11-[3R-(Hydroxymethyl)-4-oxo-2R-oxetanyl]-3,5,7R-trimethyl-2E,4E-undecadienoic acid
Alternate Names:
L-659699; Antibiotic 1233A; Antibiotic F244
Molecular Weight:
324.41
Molecular Formula:
C18H28O5
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
96% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Fluvastatin Na | HMG CoA reductase inhibitor

CAS:
93957-55-2
Catalog Number:
10-2554
Activity:
HMG CoA reductase inhibitor
Chemical Name:
(+/-)(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt
Molecular Weight:
466.45
Molecular Formula:
C24H25FNO4 . Na
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Water (up to 10 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Metabolites

Piericidin A | Mitochondrial complex I inhibitor

CAS:
2738-64-9
Catalog Number:
10-3467
Activity:
Mitochondrial complex I inhibitor
Chemical Name:
2-(10-hydroxy-3,7,9,11-tetramethyl-2,4,7,11-tridecatetraenyl)-5,6-dimethoxy-3-methyl-4-pyridinol
Alternate Name:
Piericidin A1; Shaoguanmycin B; SN 198E; AR-054
Molecular Weight:
415.57
Molecular Formula:
C26H37NO4
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
94% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or Ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

5alpha,6alpha-Epoxycholesterol | LXR ligand

CAS:
1250-95-9
Catalog Number:
10-4545
Activity:
LXR ligand
Chemical Name:
Cholestan-5α,6α-epoxy-3β-ol
Molecular Weight:
402.65
Molecular Formula:
C27H46O2
Solubility:
Soluble in DMSO (up to 10 mg/ml) orin Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Trafficking

T0901317 | LXR Agonist

T0901317 (293754-55-9) is a  potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM.1   Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in

Autogramin-2 | Autophagy blocker / GRAMD1A inhibitor

CAS:
2375541-45-8
Catalog Number:
10-4439
Activity:
Autophagy blocker / GRAMD1A inhibitor
Chemical Name:

t-Butyl 2-[(4-propan-2-yloxybenzoyl)amino]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate

Molecular Weight:
417.53
Molecular Formula:
C21H27N3O4S
Solubility:
Soluble in DMSO (up t0 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Other

Ezetimibe | Cholesterol absorption inhibitor

CAS:
163222-33-1
Catalog Number:
10-2027
Activity:
Cholesterol absorption inhibitor
Chemical Name:
(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidine-2-one
Alternate Names:
SCH 58235; Ezetrol
Molecular Weight:
409.43
Molecular Formula:
C24H21F2NO3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml)
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Filipin III | Cholesterol probe

CAS:
480-49-9
Catalog Number:
10-1490
Activity:
Cholesterol probe
Source:
Isolated from Streptomyces filipinensis
Molecular Weight:
654.85
Molecular Formula:
C35H58O11
Solubility:
Soluble in Methanol (up to 10 mg/ml)
Physical Properties:
White or light yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in methanol may be stored under inert gas at -20°C for up to 2 months.
Shipping Code:
RT