Modify Search
Select all
Products
Pages
Posts
Modify Search
Select all
Products
Pages
Posts

CL-316243 | ß3-adrenergic agonist / antiobesity

CAS:
151126-84-0
Catalog Number:
10-1450
Activity:
β3-adrenergic agonist / antiobesity
Chemical Name:
5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
Molecular Weight:
465.8
Molecular Formula:
C20H18ClNNa2O7
Solubility:
Soluble in Water (up to 50 mg/ml).
Physical Properties:
Off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
Shipping Code:
RT

CL-316243 (151126-84-0) is a potent and selective β3-adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and decreases blood insulin and glucose levels.1 CL-316243 induces functionally active mitochondrial uncoupling protein (UCP) in white fat.2 Active in vivo.

References/Citations:

1) Yoshida et al. (1994), Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist in yellow KK mice; Life Sci., 54 491
2) Yoshida et al. (1998), β3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers; Am. J. Physiol., 274 E469

CL-316243 | ß3-adrenergic agonist / antiobesity is also available in the Cellular Metabolism Library.
CAS:
151126-84-0
Catalog Number:
10-1450
Activity:
β3-adrenergic agonist / antiobesity
Chemical Name:
5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
Molecular Weight:
465.8
Molecular Formula:
C20H18ClNNa2O7
Solubility:
Soluble in Water (up to 50 mg/ml).
Physical Properties:
Off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Add to Quote

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee