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Cyclic Nucleotides

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  • 8-pCPT-2-O-Me-cAMP-AM | Epac elevator
    $148.00
    8-pCPT-2-O-Me-cAMP-AM (1152197-23-3) is a potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator1. Induces RAP1 activation and insulin secretion in pancreatic beta cell lines2-5. Induces vascular...

  • Amiodarone HCl | PDE inhibitor
    $45.00
    Amiodarone HCl (19774-82-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 μM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA2. Does not inhibit PDE8 or PDE93...

  • BC-11-38 | 686770-80-9 | Structure | Supplier
    $90.00
    A potent and selective inhibitor of phosphodiesterase PDE11 (IC50=0.28 mM).1  IC50s for PDE1-10 are greater than 100 mM. Restores the ability of p54nrb / NONOKD cells to generate cAMP in response to ACTH stimulation and...

  • BML-288 | 851-55-3 | Structure | Supplier
    $55.00
    BML-288 (851-55-3) is a potent and selective inhibitor of phosphodiesterase PDE2, IC50 = 40 nM. More potent than EHNA, another commonly used PDE2 inhibitor. Displays no effect on a panel of over 80 receptors, ion channels...

  • BRL-50481 | 433695-36-4 | Structure | Supplier
    $60.00
    BRL-50481 (433695-36-4) is a potent and selective inhibitor of phosphodiesterase-7 (PDE7), Ki=180 nM.1 Induces apoptosis in chronic lymphocytic leukemia cells which express PDE7B.2 BRL-50481 increases...

  • Cilostamide | PDE3 inhibitor
    $60.00
    Cilostamide (68550-75-4) is a selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and 50 nM)1,2. Blocks PKB/Akt signaling pathway downstream via inhibition of...

  • Cilostazol | 73963-72-1 | Structure | Supplier
    $60.00
    Cilostazol (73963-72-1) is a clinically approved phosphodiesterase III (PDE3) inhibitor (IC50 = 0.2 μM) and anti-thrombotic agent. It inhibits platelet aggregation and is a direct arterial vasodilator...

  • Dipyridamole | 58-32-2 | Structure  | Supplier
    $22.00
    Dipyridamole (58-32-2) is a phosphodiesterase inhibitor (IC50=0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively.1,2 Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor Ki=8.2 nM vs. 144.8...

  • EPAC 5376753 | EPAC inhibitor
    $60.00
    EPAC 5376753 is an allosteric inhibitor of Epac1, IC50= 4 μM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by Epac including cAMP-induced increase in migration of cardiac fibroblasts...

  • Forskolin | Adenylate cyclase activator
    $58.00
    Forskolin (66575-29-9) is a widely used adenylate cyclase activator.1 Forskolin also is a positive inotropic agent, vasodilator and induces platelet activation among other activities.2-5 References/Citations1) Awad et al...

  • IBMX is a pan-specific inhibitor of phosphodiesterases
    $30.00
    IBMX (28822-58-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 µM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA2. IBMX does not inhibit PDE8 or PDE93...

  • Ibudilast | Neuroinflammation inhibitor
    $40.00
    Phosphodiesterase inhibitor with some selectivity for PDE4 and 5. (IC50s= 53, 35, 48, 12 and 10 μM for PDE 1a, 2, 3, 4 and 5 respectively1). Acts as a cerebral vasodilator by selectively inducing a cGMP-independent...

  • Mycophenolate mofetil | Immunomodulator
    $35.00
    Mycophenolate mofetil (128794-94-5) is a mycophenolic acid prodrug. Immunosuppressive agent useful in prevention of organ allograft rejection1. Mycophenolate mofetil is metabolized to mycophenolic acid (Cat.# 10-2087) in...

  • Mycophenolic acid | Immunosuppressant
    $70.00
    Mycophenolic acid (24280-93-1) is an immunomodulator1 that blocks the biosynthesis of guanine nucleotides via inhibition of inosine 5'-monophosphate dehydrogenase. This in turn suppresses the production of proinflammatory...

  • NKY-80 | 299442-43-6 | Structure | Supplier
    $58.00
    NKY-80 (299442-43-6) is a potent and selective adenylyl cyclase inhibitor. Selective for AC5 and over AC3 and AC2 (IC50 = 8.3 μM, 132 μM and 1.7 mM respectively)1,2. More recently shown to indiscriminantly inhibit AC63...

  • Resveratrol | 201-36-0 | Structure | Supplier
    $45.00
    Resveratrol (501-36-0) is a naturally occurring phenolic antioxidant. Displays antitumor and antiplatelet effects1. Activates SIRT1 and increases longevity in yeast2. Resveratrol ameliorates ageing-related phenotypes by...

  • Ro 13-6438 | Quazinone | 70018-51-8 | Structure | Supplier
    $75.00
    Ro 13-6438 (70018-51-8) is a selective inhibitor of phosphodiesterase III (PDE III, IC50 = 0.6 μM). References/Citations1) Eigenmann et al. (1984) Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent...

  • RO 20-1724 | 28825-17-5 | Structure | Supplier
    $45.00
    RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable References/Citations1) Soderling et al. (1998), Cloning and...

  • Rolipram | 61413-54-5 | Structure | Supplier
    $60.00
    Rolipram (61413-54-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 1 μM. Displays beneficial effects in neurodegenerative diseases. Rolipram also displays anti-inflammatory activity and...

  • STF034307 | Structure | Supplier
    $60.00
    ST-034307 (133406-29-8) is a novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM. Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC1.1 It was also shown to inhibit...

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