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BiochemicalTargets

Cytoskeleton

The cytoskeleton is the structure that maintains a cell’s shape, internal organization, and provides support for essential cellular functions such as movement and division. It spans the cytoplasm and connects the cell nucleus with the extracellular matrix. Three main types of filamentous proteins comprise the cytoskeleton in eukaryotes: Microtubules (tubulin polymer) are the largest filament and are involved in maintaining the structure of the cell, cell division, providing a platform for intracellular transport, and moving various organelles and vesicles. Actin filaments are the smallest and are involved in specialized cell shapes, cytokinesis, and cell movement. There are several types of intermediate filaments (i.e. desmin, lamin, vimentin) but all are strong and involved in mechanical support of cellular structures. Pathologies related to cytoskeletal protein dysfunction include cancer, neurodegeneration, cardiovascular disease, pulmonary fibrosis and cirrhosis.

Actin

Cytochalasin B | Actin filament disrupting agent

CAS:
14930-96-2
Catalog Number:
10-2069
Activity:
Actin filament disrupting agent
Fermentation product:
from Drechslera dematioidea
Alternate Name:
NSC107658; Phominone
Molecular Weight:
479.61
Molecular Formula:
C29H37NO5
Solubility:
Soluble in DMSO (up to 5 mg/ml); Ethanol (10 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Latrunculin A | Inhibits actin polymerization and microfilament organization

CAS:
76343-93-6
Catalog Number:
10-2254
Activity:
Inhibits actin polymerization and microfilament organization
Molecular Weight:
421.55
Molecular Formula:
C22H31NO5S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
B

Mycalolide B | Actin depolymerizing agent

CAS:
122752-21-0
Catalog Number:
10-2217
Activity:
Actin depolymerizing agent
Source:
From Mycale sp.
Molecular Weight:
1027.16
Molecular Formula:
C52H74N4O17
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Kinesin

BTB-1 | Mitotic kinesin Kif18A inhibitor

CAS:
86030-08-2
Catalog Number:
10-1543
Activity:
Mitotic kinesin Kif18A inhibitor
Chemical Names:
4-Chloro-2-nitro-1-(phenylsulfonyl)benzene; NSC 156750
Molecular Weight:
297.71
Molecular Formula:
C12H8ClNO4S
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
White to off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Monastrol | Kinesin Eg5 and mitosis inhibitor

CAS:
254753-54-3
Catalog Number:
10-2629
Activity:
Kinesin Eg5 and mitosis inhibitor
Chemical Name:
1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester
Molecular Weight:
292.35
Molecular Formula:
C14H16N2O3S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

K858 | Kinesin Eg5 inhibitor

CAS:
72926-24-0
Catalog Number:
10-1312
Activity:
Kinesin Eg5 inhibitor
Chemical Name:
N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
Molecular Weight:
277.35
Molecular Formula:
C13H15N3O2S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Microtubules

Spastazoline | Spastin inhibitor

Spastazoline (2351882-11-4) in as ATP-competitive inhibitor (IC50 = 99 nM) of the microtubule-severing AAA protein spastin.  It is selective against four related AAA proteins (XL-katarin, Hs-FIGL1, Mm-VCP,

BO-264 | TACC3 inhibitor

CAS:
2408648-20-2
Catalog Number:
10-4685
Activity:
TACC3 inhibitor
Chemical Names:
3-(4-Methoxyphenyl)-N-(2-morpholin-4-ylpyrimidin-4-yl)-1,2-oxazol-5-amine
Molecular Weight:
353.38
Molecular Formula:
C18H19N5O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Septins

Forchlorfenuron | Inhibits septin dynamics

CAS:
68157-60-8
Catalog Number:
10-3090
Activity:
Inhibits septin dynamics
Chemical Name:
1-(2-Chloro-4-pyridyl)-3-phenylurea
Alternate Names:
FCF, KT-30, CPPU
Molecular Weight:
247.68
Molecular Formula:
C12H10ClN3O
Solubility:
Soluble in DMSO or Ethanol
Physical Properties:
White or off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date ofpurchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT