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Cytoskeleton

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  • Ansamitocin P3 | Microtubule depolymerizer
    $100.00
    Ansamitocin P3 (66547-09-9) is a fungal metabolite from Actinosynnema pretiosum which binds to the phomopsin A/rhizoxin site on tubulin.1,2 Ansamitocin P3 is a maytansine analog which displays potent cytotoxicity...

  • Colchicine | Microtubule depolymerizer
    $40.00
    Colchicine (64-86-8) is a naturally occurring alkaloid which acts as an antimitotic agent by binding to tubulin and depolymerizing microtubules. Colchicine induces apoptosis in a variety of cell lines...

  • Cytochalasin D | Disrupts actin filaments
    $63.00
    Cytochalasin D (22144-77-0) is a potent inhibitor of actin polymerization which also causes the disruption of actin filaments. More potent that cytochalasin B (10-fold) and does not inhibit monosaccharide transport across...

  • Docetaxel | Microtubule stabilizing agent
    $60.00
    Docetaxel (114977-28-5) is an antimitotic chemotherapeutic which inhibits via reversible high-affinity binding to microtubules1. Induces apoptosis in a variety of cancer cell lines2 however, tumor cells can quickly develop...

  • Epothilone B | Microtubule stabilizing agent
    $85.00
    Epothilone B (152044-54-7) induces microtubule polymerization. Causes cell cycle arrest at the G2-M transition (EC50 = 32 nM for HeLa cells). Induces apoptosis. Cell permeable. References/Citations1) Goodin et al. (2004),...

  • Griseofulvin | Inhibitor of centrosomal clustering
    $45.00
    Griseofulvin (126-07-8) is an antifungal antimitotic agent. Induces apoptosis of human germ cell tumor cells via disruption of connexin 43/tubulin association concomitant with enhanced translocation of connexin 43 from the...

  • K-858 | 72926-24-0 | Structure | Supplier
    $60.00
    K-858 (72926-24-0) is a selective mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM) which acts in an ATP-noncompetitive manner1,2. It is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily...

  • Latrunculin A | Inhibits actin polymerization and microfilament organization
    $98.00
    Latrunculin A (76343-93-6) inhibits actin polymerization and disrupts microfilament organization1. Significantly more potent than cytochalasins in the disruption of microfilamament mediated processes.2 Active in cell culture...

  • Latrunculin B | Inhibits actin polymerization and microfilament organization
    $40.00
    Latrunculin B (76343-94-7) inhibits actin polymerization and disrupts microfilament organization1. Significantly more potent than cytochalasins in the disruption of microfilamament mediated processes2, causes shortening and...

  • Monastrol | Kinesin Eg5 and mitosis inhibitor
    $80.00
    Monastrol (254753-54-3) is a potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles.1 Does not affect other motor proteins or tubulin. Specifically...

  • Nocodazole | Microtubule inhibitor
    $60.00
    Nocodazole (31430-18-9) is an antimitotic agent that disrupts microtubules by binding to β tubulin and thereby inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi...

  • S-Trityl-cysteine | 2799-07-7 | Structure | Supplier
    $35.00
    S-Trityl-cysteine (2799-07-7) is a cell permeable inhibitor of mitotic kinesin Eg5 (IC50 for inhibition of basal ATPase activity = 1 μM; IC50 for inhibition of microtubule-activated ATPase activity = 140 nM). Mean growth...

  • Taxol | Microtubule stabilizing agent
    $50.00
    Taxol (33069-62-4) is a clinically useful cancer chemotherapeutic agent for the treatment of breast, non-small cell lung and ovarian cancer.1 Taxol acts as a promoter of tubulin polymerization and stabilizes microtubules in...

  • Vinblastine sulfate | Microtubule depolymerizer
    $48.00
    Vinblastine sulfate (143-67-9) is a semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation.1 Inhibits normal microtubule assembly and induces aberrant...

  • Vincristine sulfate | Microtubule depolymerizer
    $62.00
    Vincristine sulfate (2068-78-2) arrests cell cycle at G2/M by interfering with mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins.1,2 Induces apoptosis...

  • Wiskostatin | 253449-04-6 | Structure | Supplier
    $55.00
    Wiskostatin (253449-04-6) is a selective, reversible inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity1. Binds to the regulatory domain of N-WASP and inhibits activation of Arp2/3 complex by forcing...

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