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Deguelin | Akt inhibitor

CAS:
522-17-8
Catalog Number:
10-2276
Activity:
Akt inhibitor
Molecular Weight:
394.43
Molecular Formula:
C23H22O6
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Light yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Deguelin (522-17-8) inhibits Akt.1,2 Induces apoptosis in a variety of cells.2,3 Displays cancer chemopreventive activity.4 Deguelin is cell permeable and active in vivo.

References/Citations:

1) Chun et al. (2003), Effects of deguelin on the phosphatidylinositol 3- kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells; J. Natl. Cancer Inst., 95 291
2) Kang et al. (2012), Deguelin, an AKT Inhibitor, Down-Regulates NFκB Signaling and Induces Apoptosis in Colon Cancer Cells and Inhibits Tumor Growth in Mice; Dig. Dis. Sci., 57 2873
3) Lee et al. (2004), Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells; Biochem. Pharmacol., 68 1119
4) Ito et al. (2004), Cancer chemopreventive activity of rotenoids from Derris trifoliata; Planta Med., 70 8

Deguelin | Akt inhibitor is also available in the Cellular Metabolism Library.
CAS:
522-17-8
Catalog Number:
10-2276
Activity:
Akt inhibitor
Molecular Weight:
394.43
Molecular Formula:
C23H22O6
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Light yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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