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Insulin

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  • 8-pCPT-2-O-Me-cAMP-AM | Epac elevator
    $148.00
    8-pCPT-2-O-Me-cAMP-AM (1152197-23-3) is a potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator1. Induces RAP1 activation and insulin secretion in pancreatic beta cell lines2-5. Induces vascular...

  • BI-6015 | 93987-29-2 | Structure | Supplier
    $48.00
    BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to...

  • BRD-7389 | 376382-11-5 | Structure | Supplier
    $80.00
    BRD-7389 (376382-11-5) inhibits p90 ribosomal S6 kinase (RSK), IC50 = 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively.1 Induces a β-cell-like state in pancreatic α-cells and induces insulin...

  • Cerulenin | Fatty Acid Synthase inhibitor
    $90.00
    Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM.1 Cerulenin produces...

  • Efaroxan HCl | 89197-00-2 | Structure | Supplier
    $80.00
    Efaroxan HCl (89197-00-2) is a selective α2-adrenergic receptor antagonist1 (selectivity ratio of α2/α1 = 724)4 and imidazoline receptor antagonist2. Induces release of insulin in the rat insulinoma cell...

  • FSG67 | GPAT inhibitor
    $55.00
    FSG67 (1158383-34-6) is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM.1 It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid...

  • Glyburide | 10238-21-8 | Structure | Supplier
    $30.00
    Glyburide (10238-21-8) is a second generation oral hypoglycemic agent. Acts via ATP-dependent K+ channel (Kir6, KATP) block.1 Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin...

  • GSK-137647 | GPR120 agonist
    $90.00
    GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively1. GSK-137647 enhances...

  • GW1100 | GPR40 antagonist
    $60.00
    GW1100 (305974-70-9) is a selective antagonist of GPR40. GW1100 inhibits GRP40-mediated Ca2+ increases stimulated GW9508 (Cat.# 10-1108) or linoleic acid (pIC50 = 5.99 for either agonist).1 The effects of GPR40 activation on...

  • ISX9 | 832115-62-5 | Structure | Supplier
    $70.00
    ISX9 (832115-62-5) promotes neurogenesis in vivo enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts and enhances memory.1 Induces robust neuronal differentiation in adult neural...

  • Oltipraz | Nrf2 activator
    $39.00
    Ortipraz (64224-21-1) upregulates the transcription factor NRF2 and prevents insulin resistance and obesity induced by high fat diet in C57BL/6J mice1. Attenuates the progression of fibrosis in a rat model of nonalcoholic...

  • Teprenone | HSP70 inducer
    $50.00
    Teprenone (6809-52-5) induces expression of HSP70 after various types of stimuli.1,2 Protects against visceral adipocity and insulin resistance in high fat fed mice.3 Teprenone displays protective effects via enhanced...

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