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Dienamide A2 | Novel cannabinoid CB2 agonist; antiinflammatory

Dienamide A2 (24738-51-0) is an analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFα mRNA expression in human monocytes/macrophages via the CB2 receptor.1 Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively)2. It elevates intracellular Ca2+ levels in CB2-positive  but not in CB2-negative cells and this effect was blocked by SR144528. It significantly inhibits LPS-induced TNFα and IL-1β expression in a CB2-independent manner.2

References/Citations

1) Gertsch et al. (2004), Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways; FEBS Lett., 577 563
2) Raduner et al. (2006), Alkylamides from Echinacea are a new class of cannabinomimetics.  Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects; J. Biol. Chem., 281 14192

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Dienamide A2 | 24738-51-0 | Structure | Supplier

Catalog#  10-1621-0005

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
24738-51-0
Catalog Number:
10-1621
Activity:
Novel cannabinoid CB2 agonist; antiinflammatory
Chemical Name:
(2E,4E)-N-Isobutyldodeca-2,4-dienamide
Molecular Weight:
251.41
Molecular Formula:
C16H29NO
Solubility:
Soluble in DMSO (up to 25 mg/ml) on in Ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Blue Ice
FeaturedDescription:
Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively)
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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