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Product Details

DMAPT | NFkB inhibitor

DMAPT (870677-05-7) is a water soluble analog of the natural plant product parthenolide (Cat.# 10-2096) which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits NFκB and stimulates the formation of reactive oxygen species which induced the activation of JNK1. In non-small cell lung cancers DMAPT inhibits NFκB and DNA double-strand break repair2.

References/Citations
1) Shanmugam et al. (2011), A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NFκB and generating reactive oxygen species; Int. J. Cancer, 128 2481
2) Estrabrook et al. (2011), Inhibition of NF-κB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays; Free Radic. Biol. Med., 51 2249

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Catalog#  10-2825

$58.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
870677-05-7
Catalog Number:
10-2825
Activity:
NFκB inhibitor
Chemical Name:
Dimethylamino-parthenolide
Molecular Weight:
293.41
Molecular Formula:
C17H27NO3
Solubility:
Soluble in DMSO, Ethyl acetate, or Ethanol.
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO, ethanol, or ethyl acetate may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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