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Topoisomerase

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  • Camptothecin | 7689-03-4 | Structure | Supplier
    $55.00
    Camptothecin (7689-03-4) is a natural product isolated from the Chinese Happy Tree, Camptotheca acuminate. It is an inhibitor of DNA topoisomerase I. Camptothecin binds irreversibly to the topoisomerase I /DNA complex...

  • Doxorubicin HCl | DNA damaging agent
    $70.00
    Doxorubicin HCl (25316-40-9) is an antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Doxorubicin HCl induces apoptosis in a variety of cell lines2. Acts as a substrate for MDR13...

  • Epirubicin HCl | DNA damaging agent
    $85.00
    Epirubicin HCl (56390-09-1) is an antitumor agent1. Inhibits topoisomerase II2. Induces DNA damage by a number of different mechanisms including intercalation, free radical-mediated oxidation, crosslinking, interference with...

  • Etoposide | 33419-42-0 | Structure | Supplier
    $68.00
    Etoposide (33419-42-0) is a chemotherapeutic agent that forms a ternary complex with DNA and topoisomerase II, preventing re-ligation of DNA strands causing DNA cleavage. Etoposide blocks the cell cycle in S-phase and...

  • Fascaplysin | 114718-57-2 | Structure | Supplier
    $40.00
    Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1...

  • Irinotecan HCl | Topoisomerase I inhibitor
    $99.00
    Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38,...

  • SN-38 | DNA topoisomerase I inhibitor
    $75.00
    SN-38 (86639-52-3) is the active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1...

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