Ebselen | Glutathione peroxidase mimic

CAS:
60940-34-3
Catalog Number:
10-2288
Activity:
Glutathione peroxidase mimic
Alternate Names:
PZ-51
Chemical Name:
2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Molecular Weight:
274.18
Molecular Formula:
C13H9NOSe
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Physical Properties:
Light yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$45.00
100 mg$110.00

Ebselen (60940-34-3) is a novel nontoxic selenium-containing multifunctional antioxidant and anti-inflammatory agent.1 Displays protective effects in reperfusion injury and stroke.2 Ebselen is an excellent scavenger of peroxynitrite.3 Acts as a glutathione peroxidase mimetic.4 Cell permeable.

References/Citations:

1) Schewe et al. (1995), Molecular actions of ebselen – an anti-inflammatory antioxidant; Gen. Pharmacol., 26 1153
2) Parnham et al. (2000), Ebselen: prospective therapy for cerebral ischaemia; Expert. Opin. Investig. Drugs, 9 607
3) Masumoto et al. (1996), Kinetic study of the reaction of ebselen with peroxynitite; FEBS Lett., 398 179
4) Nakamura et al. (2002), Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis; J. Biol. Chem., 277 2687

CAS:
60940-34-3
Catalog Number:
10-2288
Activity:
Glutathione peroxidase mimic
Alternate Names:
PZ-51
Chemical Name:
2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Molecular Weight:
274.18
Molecular Formula:
C13H9NOSe
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Physical Properties:
Light yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee