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Product Details

FTY720 HCl | Sphingosine-1-phosphate receptor agonist

FTY720 HCl (162359-56-0) is an analog of sphingosine (Cat.# 10-2287) which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3).1 Potently inhibits regulatory T cell proliferation in vitro and in vivo.2 FTY720 HCl enhances microvascular remodeling via expansion of arterioles and capillary networks.3 Potent immunomodulator.4

References/Citations
1) Brinkmann et al. (2002), The immune modulator FTY720 targets spingosine-1-phosphate receptors; J. Biol. Chem., 277 21453
2) Wolf et al. (2009), The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo; J. Immunol., 183 3751
3) Awojoodu et al. (2013), Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis; Proc. Natl. Acad. Sci. USA, 110 13785
4) Chiba (2005), FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors; Pharmacol. Ther., 108 308

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Catalog#  10-2138

$40.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
162359-56-0
Catalog Number:
10-2138
Activity:
Sphingosine-1-phosphate receptor agonist
Alternate Names:
Fingolimod
Chemical Name:
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride
Molecular Weight:
343.94
Molecular Formula:
C19H33NO2 HCl
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 40 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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