G proteins

G proteins are fundamental signaling components of the cell. G proteins are GTPases, functioning as guanine nucleotide-binding and -hydrolyzing proteins. In the inactive state they are bound to GDP; when they bind GTP (in some cases facilitated by GPCRs), they become active, stimulating and amplifying myriad signaling pathways that ultimately regulate cell growth, differentiation, and migration.

Home >> Biochemical Targets >> G proteins

Activators

ADP-ribosylation

ME-0328 | PARP3 inhibitor

CAS:

1445251-22-8

Catalog Number:

10-1484

Activity:

PARP3 inhibitor

Chemical Name:

3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide

Molecular Weight:

321.38

Molecular Formula:

C₁₉H₁₉N₃O₂

Solubility:

Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 4 mg/ml with warming).

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Shipping Code:

3-Aminobenzamide | PARP inhibitor

CAS:

3544-24-9

Catalog Number:

10-1239

Activity:

PARP inhibitor

Alternate Names:

3-AB

Molecular Weight:

136.15

Molecular Formula:

C₇H₈N₂O

Solubility:

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 4 mg/ml).

Physical Properties:

White to tan solid

Purity:

97% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Shipping Code:

Inhibitors

CCG-4986 | RGS4 inhibitor

CAS:

7134-19-2

Catalog Number:

10-1431

Activity:

RGS4 inhibitor

Chemical Names:

Methyl-N-[(4-chlorophenyl)sulfonyl]-4-nitrobenzenesulfinimidoate

Molecular Weight:

374.81

Molecular Formula:

C₁₃H₁₁ClN₂O₅S₂

Solubility:

Soluble in DMSO (60 mg/ml); Ethanol (5 mg/ml with warming)

Physical Properties:

White solid

Purity:

>98% TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:

Candesartan | Angiotensin II antagonist

CAS:

139481-59-7

Catalog Number:

10-2049

Activity:

Angiotensin II antagonist

Chemical Name:

2-Ethoxy-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid

Alternate Names:

CV-11974

Molecular Weight:

400.45

Molecular Formula:

C₂₄H₂₀N₆O₃

Solubility:

Soluble in DMSO (up to 40 mg/ml)

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:

YM-254890 | Gq inhibitor

CAS:

568580-02-9

Catalog Number:

10-1590

Activity:

Gq inhibitor

Source:

Isolated from Chromobacterium sp.

Molecular Weight:

960.1

Molecular Formula:

C₄₆H₆₉N₇O₁₅

Solubility:

Soluble in DMSO (up to 10 mg/ml)

Physical Properties:

White or off-white lyophilized solid

Purity:

95% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

Catalog Number:

10-4434

Activity:

Dual Rac/Cdc42 inhibitor

Chemical Names:

1-(9-Ethyl-9H-carbazol-3-yl)-5-phenyl-1H-1,2,3-triazole

Molecular Weight:

338.41

Molecular Formula:

C₂₂H₁₈N₄

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:

G proteins

Activators

ADP-ribosylation

ME-0328 | PARP3 inhibitor

3-Aminobenzamide | PARP inhibitor

Inhibitors

CCG-4986 | RGS4 inhibitor

Candesartan | Angiotensin II antagonist

YM-254890 | Gq inhibitor

Small G proteins

MRTX849 | Covalent KRAS^G12C Inhibitor

AMG 510 |Covalent KRAS^G12C Inhibitor

MBQ-167 | Dual Rac/Cdc42 inhibitor

Uncouplers

Other

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

G proteins

Activators

ADP-ribosylation

Inhibitors

Small G proteins

Uncouplers

Other

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules Plymouth Meeting, PA USA1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21