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Galanthamine HBr | Acetylcholinesterase inhibitor

Galanthamine HBr (1953-04-4) is a long-acting, centrally active acetylcholinesterase inhibitor, IC50 = 410 nM1. Allosteric potentiator at neuronal nicotinic ACh receptors2. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells3. Galanthamine HBr is a clinically useful agent for symptomatic relief of Alzheimer's disease but fails to prevent progression of the disease4,5.

References/Citations
1) Racchi et al. (2004), Acetylcholinesterase inhibitors: novel activities of old molecules; Pharmacol. Res., 50 441
2) Samochocki et al. (2003), Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors; J. Pharmacol. Exp. Ther., 305 1024
3) Arias et al. (2004), Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors; Neuropharmacology, 46 103
4) Rockwood et al. (2001), Effects of a flexible galantamine dose in Alzheimer's disease: a randomized, controlled trial; J. Neurol. Neurosurg. Psychiatry, 71 589
5) Chen et al. (2007), Current experimental therapy for Alzheimer's disease; Curr. Neuropharmacol., 5 127

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Galanthamine HBr | 1953-04-4 | Structure | Supplier

Catalog#  10-1136

$25.00
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CAS:
17991
Catalog Number:
10-1136
Activity:
Acetylcholinesterase inhibitor
Chemical Name:
4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, hydrobromide
Molecular Weight:
368.27
Molecular Formula:
C17H21NO3 HBr
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Water (up to 12 mg/ml).
Physical Properties:
Lyophillized solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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