my account
Login
  Loading... Please wait...

Product Details

Genistein | Tyrosine kinase inhibitor

Genistein (446-72-0) is a naturally occurring flavonoid with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase.1,2 Phytoestrogen3 and agonist at GPR304. Displays cancer chemopreventive activity.5

References/Citations

1) Akiyama et al. (1987), Genistein, a specific inhibitor of tyrosine-specific protein kinases; J. Biol. Chem., 262 5592
2) Linassier et al. (1990), Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor if EGF receptor tyrosine kinase Biochem. Pharmacol., 39 187
3) Dang et al. (2003), Peroxisome proliferator-activated receptor gamma (PPARgamma) as a molecular target for the soy phytoestrogen genistein; J. Biol. Chem., 278 962
4) Vivacqua et al. (2006), 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30; Mol. Phamracol., 70 1414
5) Sarker and Li (2002), Mechanisms of cancer chemoprevention by soy isoflavone genistein; Cancer Metastasis Rev., 21 265

swipe
Image 1

Catalog#  10-2139-0020

$30.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
446-72-0
Catalog Number:
10-2139
Activity:
Tyrosine kinase inhibitor
Chemical Name:
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Alternate Names:
4’,5,7-Trihydroxyisoflavone
Molecular Weight:
270.24
Molecular Formula:
C15H10O5
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 4 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Share Focus

Connect with Focus

Click the button below to add the Genistein | Tyrosine kinase inhibitor to your wish list.