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GPCR's

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  • 20(S)-Hydroxycholesterol | Smoothened activator
    $45.00
    20-(S)-Hydroxycholesterol (516-72-3) is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic...

  • 27-Hydroxycholesterol | Cholesterol oxidation metabolite
    $40.00
    27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild...

  • 6,7-ADTN HBr | Dopamine D1 agonist
    $60.00
    6,7-ADTN HBr (13575-86-5) is a broad spectrum dopamine receptor agonist.1,2  Demonstrates a marked selectivity for the human dopamine D3 receptor.3 6,7-ADTN and psychostimulants such as cocaine and amphetamine reduce...

  • ABT-418 HCl | Nicotinic acetylcholine receptor agonist; cognition enhancer
    $90.00
    Agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1 Displays anxiolytic activity in a rat...

  • AH-6809 | 33458-93-4 | Structure | Supplier
    $60.00
    AH-6809 (33458-93-4) is a selective PGE2 receptor (EP1) antagonist. At concentrations higher than 10 μM PGD2 and TXA2 receptors are also blocked. References/Citations1) Coleman in Prostaglandins and Related Substances: A...

  • AH-7614 | GPR120 antagonist
    $45.00
    AH-7614 (6326-06-3) is a selective antagonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pIC50s= 7.1 and 1. References/Citations1) Sparks et al. (2014), Identification of diarylsulfonamides as agonists of...

  • Anandamide | Endogenous cannabinoid
    $35.00
    Anandamide (94421-68-8) is an endogenous cannabinoid receptor agonist.1-3 Ki=89 nM for CB1 and 371 nM for CB2 receptors. References/Citations1) Devane et al. (1992), Isolation and structure of a brain constituent that binds...

  • Apomorphine HCl | 41372-20-7 | Structure | Supplier
    $40.00
    Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse model.2 In clinical use for Parkinson’s...

  • Arecoline HBr | ACAT1 inhibitor
    $30.00
    Arecoline (300-8-3) is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA...

  • Aripiprazole | Dopamine receptor partial agonist
    $40.00
    Aripiprazole (129722-2-9) is a clinically useful neuroleptic and antipsychotic agent.1 Dopamine D2 receptor antagonist and autoreceptor agonist.2 Improves symptoms of psychosis associated with Alzheimer's disease...

  • Astemizole | 68844-77-9 | Structure | Supplier
    $56.00
    Astemizole (68844-77-9) is an antagonist at the histamine H1 receptor. References/Citations1) Richards et al. (1984), Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy; Drugs, 28 38 2) Laduron...

  • Benzotript | Cholecystokinin antagonist
    $40.00
    Benzotript (39544-74-6) antagonizes the interaction of cholecystokinin and related peptides with the cholecystokinin receptor.1  It has been reported to potentiate morphine analgesia via interaction with opioid...

  • Benztropine mesylate | Induces remyelination of neurons
    $38.00
    Benztropine mesylate (132-17-2) is a centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1 Also inhibits the dopamine transporter (Ki=160 nM).2 Benztropine mesylate enhances remyelination and...

  • Bromocriptine mesylate | 22260-51-1 | Structure | Supplier
    $65.00
    Bromcriptine mesylate (22260-51-1) is a dopamine D2 receptor agonist. Inhibits prolactin production3. Decreases cocaine self-administration in the rat4. Active in vivo. References/Citations1) Nilsson and Hokfelt (1978),...

  • Cinnabarinic acid | Endogenous AhR ligand
    $50.00
    Cinnabarinic acid (606-59-7) is a novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist.1 It drives IL-22 production by stimulating the differentiation of human and mouse T cells...

  • CL-316243 | 151126-84-0 | Structure | Supplier
    $80.00
    CL-316243 (151126-84-0) is a potent and selective β-3 adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and...

  • Clozapine | 5786-21-0 | Structure | Supplier
    $30.00
    Clozapine (5786-21-0) is a dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM).1 Atypical neuroleptic agent.2 Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7...

  • Clozapine-N-oxide | DREADD agonist
    $78.00
    Clozapine-N-oxide (34233-69-7) is a clozapine metabolite1 which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2...

  • CUR 61414 | 334998-26-6 | Structure | Supplier
    $90.00
    CUR 61414 (334998-26-6) is a novel Hedgehog signaling pathway inhibitor (IC50=100-200 nM). Selectively binds to Smo but not other GPCRs. CUR 61414 blocks the formation of and induces the regression of basaloid lesions in...

  • Cyclopamine | 4449-51-8 | Structure | supplier
    $45.00
    Cyclopamine (4449-51-8) is a naturally occurring steroidal alkaloid with teratogenic activity. Blocks sonic hedgehog signaling by binding to smoothened. Antitumor activity. Cell Permeable. References/Citations1) Watkins et...

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