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BiochemicalTargets

GPCRs

GPCRs are large, seven-transmembrane receptors in the plasma membrane of the cell. They associate with G proteins, assisting in their GTPase activation and subsequent signal transduction. These pathways involve messengers such as phosphatidylinositol, cyclic AMP (cAMP), and diacylglycerol (DAG) and control important processes like neuronal signaling, cell growth, differentiation, and migration.

Acetylcholine

Bupropion HCl | Monoamine transporter inhibitor

CAS:
31677-93-7
Catalog Number:
10-2462
Activity:
Monoamine transporter inhibitor
Chemical Names:
1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
Molecular Weight:
276.20
Molecular Formula:
C13H18ClNO·HCl
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Adenosine

Preladenant | Potent and selective adenosine A2A antagonist

CAS:
377727-87-2
Catalog Number:
10-4102
Chemical Name:
4-(Furan-2-yl)-10-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine
Alternate Name:
SCH 420814
Molecular Weight:
503.57
Molecular Formula:
C29H29N9O3
Solubility:
Soluble in DMSO (up to 5 mg/ml with warming).
Physical Properties:
Beige solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

CPI-444 | Adenosine A2A receptor antagonist

CAS:
1202402-40-1
Catalog Number:
10-4101
Activity:
Adenosine A2A receptor antagonist
Chemical Name:
7-(5-Methylfuran-2-yl)-3-[[6-[[(3S)-oxolan-3-yl]oxymethyl]pyridine-2-yl]triazolo[4,5-d]pyrimidin-5-amine
Alternate Name:
Ciforadenant
Molecular Weight:
407.43
Molecular Formula:
C20H21N7O3
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Reversine | Reverses differentiated cells to multipotent stem cells

CAS:
656820-32-5
Catalog Number:
10-1154
Activity:
Reverses differentiated cells to multipotent stem cells
Chemical Name:
2-(4-Morpholinoanilino)-6-cyclohexylaminopurine
Molecular Weight:
383.5
Molecular Formula:
C21H27N7O
Solubility:
Soluble in DMSO (up to 7 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
Shipping Code:
RT

Adrenoceptor

Mirabegron | beta-3 Adrenergic agonist

Mirabegron (223673-61-8) is a potent (EC50 = 22.4 nM CHO cells expressing human ß3-ARs) beta-3 adrenergic receptor (ß3-AR) agonist with high selectivity over the beta-1 and

Formoterol hemifumarate | ß2 adrenergic agonist

CAS:
43229-80-7
Catalog Number:
10-5092
Activity:
Potent and selective β2 adrenergic agonist
Chemical Name:
(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide
Molecular Weight:
402.44
Molecular Formula:
C19H24N2O4·1/2C4H4O4
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
White to off-white solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Terazocin HCl | Adrenergic antagonist

CAS:
63074-08-8
Catalog Number:
10-2379
Activity:
Adrenergic antagonist
Chemical Name:
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl-4-[(tetrahydro-2-furanyl)carbonyl]piperazine
Molecular Weight:
423.88
Molecular Formula:
C19H25N5O4
Solubility:
Soluble in Water (up to 20 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Cannabinoid

N-Arachidonoyldopamine | Endogenous TRPV1 activator

CAS:
199875-69-9
Catalog Number:
10-1479
Activity:
Endogenous TRPV1 activator
Chemical Name:
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)dopamine
Alternate Name:
NADA; AA-DA
Molecular Weight:
439.63
Molecular Formula:
C28H41NO3
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Pale yellow viscous oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-80° (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Subject to air oxidation Solutions in DMSO may be stored at -80° under an inert atmosphere for up to 1 month.
Shipping Code:
Blue Ice

AM251 | Cannabinoid CB1 antagonist

CAS:
183232-66-8
Catalog Number:
10-2007
Activity:
Cannabinoid CB1 receptor antagonist
Chemical Name:
N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Molecular Weight:
555.24
Molecular Formula:
C22H21Cl2IN4O
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 13 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Dienamide A2 | Novel cannabinoid CB2 agonist/antiinflammatory

CAS:
24738-51-0
Catalog Number:
10-1621
Activity:
Novel cannabinoid CB2 agonist; antiinflammatory
Chemical Name:
(2E,4E)-N-Isobutyldodeca-2,4-dienamide
Molecular Weight:
251.41
Molecular Formula:
C16H29NO
Solubility:
Soluble in DMSO (up to 25 mg/ml) on in Ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Blue Ice

Chemokine

Plerixafor | CXCR4 antagonist

CAS:
155148-31-5
Catalog Number:
10-2864
Activity:
CXCR4 antagonist
Molecular Weight:
794.48
Molecular Formula:
C28H54N8 • 8HCl
Solubility:
Soluble in Water (up to at least 55 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

PF-4136309 | CCR2 antagonist

CAS:
1341224-83-6
Catalog Number:
10-4261
Activity:
CCR2 antagonist
Chemical Name:
N-[2-[(3S)-3-[[4-Hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Alternate Name:
INCB8761
Molecular Weight:
568.60
Molecular Formula:
C29H31F3N6O3
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Maraviroc | CCR5 Antagonist

CAS:
376348-65-1
Catalog Number:
10-4260
Activity:
CCR5 Antagonist
Chemical Name:
4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
Molecular Weight:
513.68
Molecular Formula:
C29H41F2N5O
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Alternate Name:
UK-427,857

Dopamine

9-Hydroxyrisperidone | Risperidone metabolite

CAS:
144598-75-4
Catalog Number:
10-2300
Activity:
Risperidone metabolite
Chemical Name:
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Alternate Name:
Paliperidone
Molecular Weight:
426.48
Molecular Formula:
C23H27FN4O3
Solubility:
Soluble in DMSO (up to 4 mg/ml).
Physical Properties:
White solid
Purity:
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT

Quetiapine hemifumarate | Atypical antipsychotic agent

CAS:
111974-72-2
Catalog Number:
10-2587
Activity:
Atypical antipsychotic agent
Chemical Name:
2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate
Alternate Names:
ICI-204636
Molecular Weight:
441.54
Molecular Formula:
C21H25N3O2 • 0.5C4H4O4
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Perphenazine | Antipsychotic agent

CAS:
58-39-9
Catalog Number:
10-4709
Activity:
Typical antipsychotic
Chemical Name:
2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol
Molecular Weight:
403.98
Molecular Formula:
C21H26ClN3OS
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Estrogen

Fulvestrant | Estrogen receptor antagonist

CAS:
129453-61-8
Catalog Number:
10-2541
Activity:
Estrogen receptor antagonist
Chemical Names:
7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol; ICI- 182,780; ZD-9238
Molecular Weight:
606.77
Molecular Formula:
C32H47F5O3S
Solubility:
Soluble in DMSO (60 mg/mL); Ethanol (30 mg/mL)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

DPN |ERß agonist

CAS:
1428-67-7
Catalog Number:
10-2909
Activity:
Estrogen ERβ receptor agonist
Chemical Name:
2,3-bis(4-Hydroxyphenyl)-propionitrile
Alternate Names:
Diarylpropionitrile
Molecular Weight:
239.27
Molecular Formula:
C15H13NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

27-Hydroxycholesterol | Cholesterol oxidation metabolite

CAS:
20380-11-4
Catalog Number:
10-4536
Activity:
Cholesterol oxidation metabolite
Chemical Name:
27-Hydroxycholesterol; 5,25R-Cholesten-3β,26-diol
Molecular Weight:
402.66
Molecular Formula:
C27H46O2
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Free fatty acid

GW1100 | GPR40 antagonist

CAS:
306974-70-9
Catalog Number:
10-4516
Activity:
GPR40 antagonist
Chemical Name:
1-(4-Ethoxycarbonylphenyl-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone
Molecular Weight:
520.59
Molecular Formula:
C27H25FN4O4S
Solubility:
Soluble in DMSO (up to 2 mg/ml) or in DMF (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
96% by LCMS
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. Dilutions into aqueous media are not stable and should be used within one working day.
Shipping Code:
RT

AH-7614 | GPR120 antagonist

CAS:
6326-06-3
Catalog Number:
10-1521
Activity:
GPR120 antagonist
Chemical Name:
4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide
Molecular Weight:
351.43
Molecular Formula:
C20H17NO3S
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

DC260126 | GPR40 antagonist

CAS:
346692-04-4
Catalog Number:
10-1531
Activity:
GPR40 antagonist
Chemical Name:
N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
Molecular Weight:
307.37
Molecular Formula:
C16H18NO2S
Solubility:
Soluble in DMSO (up to 80 mg/ml) or in Ethanol (up to 80 mg/ml).
Physical Properties:
Brown waxy solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

GABA

Flumazenil | Benzodiazepine antagonist

CAS:
78755-81-4
Catalog Number:
10-1081
Activity:
Benzodiazepine antagonist
Chemical Name:

8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester

Alternate Names:

Ro 1722;  Ro 15-1788

Molecular Weight:
303.29
Molecular Formula:
C15H14FN3O3
Solubility:
Soluble in DMSO (up to 8 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Tiagabine hydrochloride | GABA transporter 1 (GAT1) inhibitor

CAS:
145821-59-6
Catalog Number:
10-4384
Activity:
GABA transporter 1 (GAT1) inhibitor
Chemical Name:
(3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid
Alternate Name:
NO-328
Molecular Weight:
412.00
Molecular Formula:
C20H25NO2S2 • HCl
Solubility:
Soluble in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml)
Physical Properties:
Off-white or beige solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Histamine

Roxatidine | Histamine H2 antagonist, antiulcer, anti-inflammatory

CAS:
78273-80-0
Catalog Number:
10-5046
Activity:
Histamine H2 antagonist, antiulcer, anti-inflammatory
Chemical Name:
2-Hydroxy-N-(3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)acetamide
Molecular Weight:
306.40
Molecular Formula:
C17H26N2O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Colorless to pale yellow oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Perphenazine | Antipsychotic agent

CAS:
58-39-9
Catalog Number:
10-4709
Activity:
Typical antipsychotic
Chemical Name:
2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol
Molecular Weight:
403.98
Molecular Formula:
C21H26ClN3OS
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Hydroxycarboxylic acid

IPBT-5CA | GPR109B agonist

CAS:
306935-41-1
Catalog Number:
10-1070
Activity:
GPR109B agonist
Alternate Names:
IBC-293
Chemical Name:
1-(1-Methylethyl)-1H-benzotriazole-5-carboxylic acid
Molecular Weight:
205.22
Molecular Formula:
C10H11N2O2
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Leukotriene

Montelukast sodium | Leukotriene antagonist and GPR17 antagonist

CAS:
151767-02-1
Catalog Number:
10-2597
Activity:
Leukotriene antagonist and GRP17 antagonist
Chemical Name:
2-[1-[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetate, sodium salt
Alternate Names:
MK-0476
Molecular Weight:
608.17
Molecular Formula:
C35H35ClNO3S
Solubility:
Soluble in DMSO (up to 60 mg/ml), in Water (up to 30 mg/ml) , or in Ethanol (up to 60 mg/ml)
Physical Properties:
Solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

BML-111 | LXA agonist/anti-inflammatory

CAS:
78606-80-1
Catalog Number:
10-3202
Activity:
LXA agonist and anti-inflammatory
Chemical Name:
(5S,6R)-Methyl 5,6,7-trihydroxyheptanoate
Molecular Weight:
192.21
Molecular Formula:
C8H16O5
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Zafirlukast | HSP70 inhibitor and leukotriene antagonist

CAS:
107753-78-6
Catalog Number:
10-1100
Activity:
Hsp70 inhibitor
Alternate Names:
ICI-204219
Molecular Weight:
575.69
Molecular Formula:
C31H33N3O6S
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White or pink solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Lysophosphatidic acid

YL-365 | GPR34 antagonist

YL-365 is a potent (IC50 = 17 nM) and selective antagonist of GPR34, a GPCR for lysophosphatidylserine.1 GPR34 is highly expressed in various immune cells and

GRI-977143 | LPA2 antagonist

CAS:
325850-80-5
Catalog Number:
10-1442
Activity:
LPA2 antagonist
Chemical Name:
2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
Molecular Weight:
391.44
Molecular Formula:
C22H17NO6S
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

H2L5186303 | LPA2 antagonist

CAS:
139262-76-3
Catalog Number:
10-1452
Activity:
LPA2 antagonist
Chemical Name:
(Z,Z)-4,4′-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid]
Molecular Weight:
488.45
Molecular Formula:
C26H202O8
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Metabotropic glutamate

MPEP HCl | mGlu5 Receptor antagonist

CAS:
219911-35-0
Catalog Number:
10-4007
Activity:
mGlu5 receptor antagonist
Chemical Name:
2-Methyl-6-(2-phenylethynyl)pyridine hydrochloride
Molecular Weight:
229.7
Molecular Formula:
C14H11N • HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
White or pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Ibotenic acid | NMDA and mGluR agonist

CAS:
2552-55-8
Catalog Number:
10-2693
Activity:
NMDA and mGluR agonist
Chemical Name:
α-Amino-3-hydroxy-5-isoxazoleacetic acid hydrate
Molecular Weight:
176.13
Molecular Formula:
C5H6N2O4 • H2O
Solubility:
Soluble in Water (up to 1 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Opioid

Naloxone HCl | Opioid receptor antagonist

CAS:
357-08-4
Catalog Number:
10-2442
Activity:
Opiod receptor antagonist
Chemical Name:
(5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-one hydrochloride
Molecular Weight:
363.84
Molecular Formula:
C19H21NO4 &bul; HCl
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Nalmefene HCl | Opioid receptor antagonist

CAS:
58895-64-0
Catalog Number:
10-1049
Activity:
Opioid receptor antagonist
Chemical Name:
5(α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylene-morphinan-3,14-diol hydrochloride
Molecular Weight:
375.82
Molecular Formula:
C21H25NO3·HCl
Solubility:
Soluble in Water (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Orphan

ML401 | EBI2 (GPR183) antagonist

ML401 (1597489-14-9) is a potent antagonist of GPR183 (IC50 = 1.03 nM), also known as EBI2 or Epstein-Barr virus-induced gene 2.  ML401 inhibited  7α,25-dihydroxycholesterol-induced RS11846 cell

PSB-1584 | GPR84 agonist

CAS:
72255-76-6
Catalog Number:
10-5373
Activity:
GPR84 agonist
Chemical Names:
6-Hexylamino-2,4(1H,3H)-pyrimidinedione, 6-Hexylaminouracil
Molecular Weight:
211.26
Molecular Formula:
C10H17N3O2
Solubility:
Soluble in DMSO (35 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
Shipping Code:
RT

PAF

WEB-2086 | PAF receptor antagonist

CAS:
105219-56-5
Catalog Number:
10-1389
Activity:
PAF receptor antagonist
Alternate Names:
Apafant
Chemical Name:
4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine
Molecular Weight:
455.96
Molecular Formula:
C22H22ClN5O2S
Solubility:
Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Ginkgolide B | PAF receptor antagonist

CAS:
15291-77-7
Catalog Number:
10-1080
Activity:
PAF antagonist
Alternate Names:
BN 52021
Chemical Name:
Natural product isolated from Ginko biloba
Molecular Weight:
424.41
Molecular Formula:
C20H24O10
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
Shipping Code:
RT

Prostanoid

Grapiprant | EP4 Receptor antagonist

CAS:
415903-37-6
Catalog Number:
10-4006
Activity:
EP4 Receptor antagonist
Chemical Name:
1—[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
Alternate Names:
CJ-023423; ARY-007
Molecular Weight:
491.61
Molecular Formula:
C26H29N5O3S
Solubility:
Soluble in DMSO (up to at least 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

TG 4-155 | EP2 receptor antagonist

CAS:
1164462-05-8
Catalog Number:
10-1574
Activity:
EP2 receptor antagonist
Chemical Name:
(2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
Molecular Weight:
394.47
Molecular Formula:
C23H26N2O4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Prostaglandin E2 | Prostaglandin E (EP) receptor agonist

CAS:
363-24-6
Catalog Number:
10-1358
Activity:
Prostaglandin E (EP) receptor agonist
Alternate Names:
Dinoprost
Chemical Name:
(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid
Molecular Weight:
352.47
Molecular Formula:
C20H32O5
Solubility:
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (greater than 25 mg/ml).
Physical Properties:
White solid
Purity:
>98% by TLC
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
Blue Ice

Serotonin

Serodolin | ß-Arrestin-biased 5-HT7 antagonist

CAS:
1814929-81-1
Catalog Number:
10-4086
Activity:
ß-Arrestin-biased 5-HT7 antagonist
Chemical Names:
1-(5-(4-(4-Fluorophenyl)piperazin-1-yl)pentyl)-1H-benzo[d]imidazole-2(3H)-one
Molecular Weight:
382.47
Molecular Formula:
C22H27FN4O
Solubility:
Soluble in DMSO (at least 50 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Dihydroergotamine mesylate | Vascular serotonin receptor agonist

CAS:
6190-39-2
Catalog Number:
10-3400
Activity:
Vascular serotonin receptor agonist
Chemical Names:
(5’a,10a)-9,10-Dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)ergotaman-3′,6′,18-trione, mesylate
Molecular Weight:
679.79
Molecular Formula:
C33H37N5O5·CH3SO3H
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Metergoline | Serotonin 5HT1,2,7 antagonist

CAS:
17692-51-2
Catalog Number:
10-3058
Activity:
Serotonin 5HT1,2,7 antagonist
Chemical Names:
[(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester
Molecular Weight:
403.52
Molecular Formula:
C25H29N3O2
Solubility:
Soluble in DMSO (40 mg/ml) or ethanol (4 mg/mL)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethaqnol may be stored at -20°C for up to 2 month.
Shipping Code:
RT

Smoothened

Purmorphamine | Smoothened activator

CAS:
483367-10-8
Catalog Number:
10-4622
Activity:
Smoothened activator
Chemical Name:
1-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Molecular Weight:
520.62
Molecular Formula:
C31H32N6O2
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

20(S)-Hydroxycholesterol | Smoothened activator

CAS:
516-72-3
Catalog Number:
10-4540
Activity:
Smoothened activator
Chemical Name:
5-Cholesten-3β, 20α-diol
Molecular Weight:
402.66
Molecular Formula:
C27H46O2
Solubility:
Soluble in DMSO or in Ethanol.
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

SAG | Smoothened agonist

CAS:
912545-86-9 (free base)
Catalog Number:
10-4525
Activity:
Smoothened agonist
Alternate Names:
Smoothened Agonist
Chemical Name:
3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiiophene-2-carboxamide dihydrochloride
Molecular Weight:
562.98
Molecular Formula:
C28H28ClN3OS 2HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml), in DMF (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Solid
Storage Temperature:
-20°
Shipping Code:
RT

Sphingosine-1-phosphate

CYM-5541 | Allosteric sphingosine-1-phosphate receptor 3 agonist

CAS:
945128-26-7
Catalog Number:
10-4493
Activity:
Allosteric sphingosine-1-phosphate receptor 3 agonist
Chemical Name:
N,N-Dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
Alternate Name:
ML249
Molecular Weight:
316.44
Molecular Formula:
C19H28N2O2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Sphingosine-1-phosphate | EDG receptor ligand

CAS:
26993-30-6
Catalog Number:
10-4526
Activity:
EDG receptor ligand
Chemical Name:
Sphingosine-1-phosphate, D-erythro
Molecular Weight:
379.47
Molecular Formula:
C18H38NO5P
Solubility:
Soluble in anhydrous methanol (up to 0.5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in methanol or in BSA/water may be stored at -20° for up to 2 months. Precipitate may form upon thawing, but will redissolve with warming.
Shipping Code:
RT

FTY720 HCl | Sphingosine-1-phosphate receptor agonist

CAS:
162359-56-0
Catalog Number:
10-2138
Activity:
Sphingosine-1-phosphate receptor agonist
Alternate Names:
Fingolimod
Chemical Name:
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride
Molecular Weight:
343.94
Molecular Formula:
C19H33NO2 HCl
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 40 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

TAAR

EPPTB | TAAR1 antagonist

CAS:
1110781-88-8
Catalog Number:
10-1199
Activity:
TAAR1 antagonist
Chemical Name:
N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide
Molecular Weight:
378.4
Molecular Formula:
C20H21F3N2O2
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT