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Cholinergics

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  • ABT-418 HCl | Nicotinic acetylcholine receptor agonist; cognition enhancer
    $90.00
    Agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1 Displays anxiolytic activity in a rat...

  • Arecoline HBr | ACAT1 inhibitor
    $30.00
    Arecoline (300-8-3) is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA...

  • Benztropine mesylate | Induces remyelination of neurons
    $38.00
    Benztropine mesylate (132-17-2) is a centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1 Also inhibits the dopamine transporter (Ki=160 nM).2 Benztropine mesylate enhances remyelination and...

  • Clozapine-N-oxide | DREADD agonist
    $78.00
    Clozapine-N-oxide (34233-69-7) is a clozapine metabolite1 which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2...

  • Ethopropazine HCl | Promotes stem cell self renewal
    $90.00
    Ethopropazine HCl (1094-08-2) is a butyrylcholinesterase inhibitor.1 Reduces drug-induced extrapyramidal motor syndrome. Parkinson's disease therapeutic.2 Alleviates thermal hyperalgesia in neuropathic rats...

  • Galanthamine HBr | 1953-04-4 | Structure | Supplier
    $25.00
    Galanthamine HBr (1953-04-4) is a long-acting, centrally active acetylcholinesterase inhibitor, IC50 = 410 nM1. Allosteric potentiator at neuronal nicotinic ACh receptors2. Prevents β-amyloid-induced apoptosis in...

  • NSC-23766 | Rac1 GTPase inhibitor
    $67.00
    NSC-23766 (733767-34-5) is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely...

  • PNU 282987 | nAChR agonist
    $40.00
    PNU 282987 (123464-89-1) is a selective a7 nicotinic acetylcholine receptor (nAChR) agonist (Ki = 26 nM).1  The a7 nAChR is a potential therapeutic target of cognitive deficits in diseases such as Alzheimers,...

  • SKF525A HCl | Cytochrome P450 inhibitor
    $50.00
    SKF-525A (62-68-0) is a commonly used non-selective Cytochrome P450 inhibitor.1  It is also a local anesthetic2 acting via blockage of the acetylcholine receptor3 – it is a commonly used reagent to stabilize the...

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