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Gabapentin lactam | Neuroprotective agent

CAS:
64744-50-9
Catalog Number:
10-2535
Activity:
Neuroprotective agent
Chemical Name:
4,4-Pentamethylene-2-pyrrolidone
Alternate Names:
GBP-L
Molecular Weight:
153.22
Molecular Formula:
C09H15NO
Solubility:
Soluble in DMSO (up to 40 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4

References/Citations:

1) Zucker et al. (2004), Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in transgenic mouse model of huntington’s disease; Nauyn Schmiedebergs Arch. Pharmacol., 370 131
2) Henle et al. (2006), Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons; J. Pharmacol. Exp. Ther., 319 181
3) Pielen et al. (2004), Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels; Graefes Arch. Clin. Exp. Ophthalmol., 242 240
4) Lagreze et al. (2001), The neuroprotective properties of gabapentin-lactam; Graefes Arch. Clin. Exp. Ophthalmol., 239 845

Gabapentin lactam | Neuroprotective agent is also available in the Cellular Metabolism Library.
CAS:
64744-50-9
Catalog Number:
10-2535
Activity:
Neuroprotective agent
Chemical Name:
4,4-Pentamethylene-2-pyrrolidone
Alternate Names:
GBP-L
Molecular Weight:
153.22
Molecular Formula:
C09H15NO
Solubility:
Soluble in DMSO (up to 40 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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