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Smoothened

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  • 20(S)-Hydroxycholesterol | Smoothened activator
    $45.00
    20-(S)-Hydroxycholesterol (516-72-3) is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic...

  • CUR 61414 | 334998-26-6 | Structure | Supplier
    $90.00
    CUR 61414 (334998-26-6) is a novel Hedgehog signaling pathway inhibitor (IC50=100-200 nM). Selectively binds to Smo but not other GPCRs. CUR 61414 blocks the formation of and induces the regression of basaloid lesions in...

  • Cyclopamine | 4449-51-8 | Structure | supplier
    $45.00
    Cyclopamine (4449-51-8) is a naturally occurring steroidal alkaloid with teratogenic activity. Blocks sonic hedgehog signaling by binding to smoothened. Antitumor activity. Cell Permeable. References/Citations1) Watkins et...

  • Jervine | Hedgehog pathway
    $85.00
    Jervine (469-59-0) is an inhibitor of Hedgehog signaling (IC50 = 0.5-0.7 μM). Binds directly to Smoothened (Smo)1. Inhibits the response of target tissues to Sonic hedgehog signaling2. Jervine induces COX-2 overexpression...

  • SAG | Smoothened agonist
    $70.00
    SAG (912545-86-9) is a smoothened agonist which bind directly to SMO and can block SMO inhibition by cyclopamine (Cat.# 10-1082). The conformation of SMO is altered by SAG binding which results in the accumulation of SMO in...

  • Vismodegib | Sonic Hedgehog signaling pathway inhibitor
    $75.00
    Vismodegib (879085-55-9) inhibits Sonic Hedgehog pathway signaling by blocking the activity of Smoothened. Inhibition of SHH leads to decreased cell viability and induction of apoptosis in a variety of cancer cell lines and...

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