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BiochemicalTargets

Growth factors

Growth factors are a diverse group of proteins, usually smaller in molecular weight, that influence cell growth by many different means. Examples include angiopoietin, interleukins, neurotrophins, fibroblast growth factor, epidermal growth factor, and transforming growth factor, and tumor necrosis factor-alpha.

BDNF

Deltamethrin | Calcineurin inhibitor/displays neurotrophic activity

CAS:
52918-63-5
Catalog Number:
10-3103
Activity:
Calcineurin inhibitor; displays neurotrophic activity
Chemical Name:
(S)-α-Cyano-3-phenoxybenzyl (1R, 3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate
Molecular Weight:
505.20
Molecular Formula:
C22H19Br2NO3
Solubility:
Soluble in DMSO (up to 50 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC and GC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

C8-Ceramide | Protein kinase activator

CAS:
74713-59-0
Catalog Number:
10-4301
Activity:
Protein kinase activator
Chemical Name:
N-Octanoyl-D-erythro-sphingosine
Molecular Weight:
425.69
Molecular Formula:
C26H51NO3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

ANA-12 | TrkB antagonist

CAS:
219766-25-3
Catalog Number:
10-2828
Activity:
TrkB antagonist
Chemical Name:
N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide
Molecular Weight:
407.49
Molecular Formula:
C22H21N3O3S
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT

EGF

Afatinib | EGFR and HER2 inhibitor

CAS:
850140-72-6
Catalog Number:
10-4510
Activity:
EGFR and HER2 inhibitor
Chemical Name:
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2E-butenamide
Alternate Names:
BIBW2992
Molecular Weight:
485.94
Molecular Formula:
C24H25ClFN5O3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Lapatinib (base) | EGFR and HER2 inhibitor

CAS:
231277-92-2
Catalog Number:
10-2147
Activity:
EGFR and HER2 inhibitor
Chemical Name:
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine
Alternate Names:
GW-572016
Molecular Weight:
581.06
Molecular Formula:
C29H26ClFN4O4S
Solubility:
Soluble in DMSO (up to 200 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Erlotinib HCl | EGFR Kinase inhibitor

CAS:
183319-69-9
Catalog Number:
10-2135
Activity:
EGFR Kinase inhibitor
Chemical Name:
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride
Molecular Weight:
429.91
Molecular Formula:
C22H23N3O4 HCl
Solubility:
Soluble in DMSO (up to 18 mg/ml with warming).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

FGF

NVP-BGJ398 | Pan-specific FGFR inhibitor

CAS:
872511-34-7
Catalog Number:
10-4817
Activity:
Pan-specific FGFR inhibitor
Chemical Name:
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)-1-methylurea
Alternate Names:
Infigratinib
Molecular Weight:
560.48
Molecular Formula:
C26H31Cl2N7O3
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

GDNF

XIB4035 | GFRα-1 agonist

CAS:
10023-54-8
Catalog Number:
10-1486
Activity:
GFRα1 agonist
Chemical Name:
(E)-N4-(7-chloro-2-(2-chlorostyryl)quinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine 3(H3PO4)
Molecular Weight:
750.45
Molecular Formula:
C26H31Cl2N3 3(H3PO4)
Solubility:
Soluble in DMSO (up to 25 mg/ml with warming).
Physical Properties:
Light brown solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

IGF

Picropodophyllotoxin | IGF1R inhibitor

CAS:
477-47-4
Catalog Number:
10-2189
Activity:
IGF1R inhibitor
Chemical Name:
(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Molecular Weight:
414.42
Molecular Formula:
C22H22O8
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
White solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Interleukins

Belnacasan | ICE/caspase-1 inhibitor

CAS:
273404-37-8
Catalog Number:
10-4399
Activity:
ICE/caspase-1 inhibitor
Chemical Names:
(S)-1-((S)-2-(4-Amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide; VX-765
Molecular Weight:
508.99
Molecular Formula:
C24H33ClN4O6
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white to white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Dienamide A2 | Novel cannabinoid CB2 agonist/antiinflammatory

CAS:
24738-51-0
Catalog Number:
10-1621
Activity:
Novel cannabinoid CB2 agonist; antiinflammatory
Chemical Name:
(2E,4E)-N-Isobutyldodeca-2,4-dienamide
Molecular Weight:
251.41
Molecular Formula:
C16H29NO
Solubility:
Soluble in DMSO (up to 25 mg/ml) on in Ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Blue Ice

Triptolide | Immunosuppressant

CAS:
38748-32-2
Catalog Number:
10-2631
Activity:
Immunsuppressant
Chemical Name:
(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
Alternate Names:
PG490
Molecular Weight:
360.40
Molecular Formula:
C20H24O6
Solubility:
Soluble in DMSO (up to 7 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

NGF

LM11A-31 | p75NTR ligand / Promotes neurogenesis

CAS:
1243259-19-9
Catalog Number:
10-1526
Activity:
p75NTR ligand / Promotes neurogenesis
Chemical Name:
(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide, dihydrochloride
Molecular Weight:
316.27
Molecular Formula:
C12H25N3O2·2HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 30 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

AG-879 | NGFR kinase inhibitor

CAS:
148741-30-4
Catalog Number:
10-1090
Activity:
NGFR kinase inhibitor
Chemical Name:
3,5-Di-t-butyl-4-hydroxybenzylidene cyanothioacetamide
Molecular Weight:
316.47
Molecular Formula:
C18H24N2OS
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

GW-441756 | NGFR kinase inhibitor

CAS:
504433-23-2
Catalog Number:
10-1023
Activity:
NGFR kinase inhibitor
Chemical Name:
1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
Molecular Weight:
275.31
Molecular Formula:
C17H13N3O
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

PDGF

TGF

IDE2 | Inducer of Definitive Endoderm

IDE2 (1136466-93-7) induces robust differentiation of embryonic stem cells into endoderm (EC50 = 223 nM) in both mouse and human cells via activation of the TGFß signaling pathway.1 It was

IDE1 | Inducer of Definitive Endoderm

IDE1 (1160927-48-9) induces robust differentiation of embryonic stem cells into endoderm (EC50 = 125 nM) in both mouse and human cells via activation of the TGFß signaling pathway.1,2 It has

GW788388 | TGF-ß receptor kinase inhibitor

CAS:
452342-67-5
Catalog Number:
10-5521
Activity:
TGF-ß receptor kinase inhibitor
Chemical Names:
4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide
Molecular Weight:
425.49
Molecular Formula:
C25H23N5O2
Solubility:
Soluble in DMSO (18 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

TNF

Dienamide A2 | Novel cannabinoid CB2 agonist/antiinflammatory

CAS:
24738-51-0
Catalog Number:
10-1621
Activity:
Novel cannabinoid CB2 agonist; antiinflammatory
Chemical Name:
(2E,4E)-N-Isobutyldodeca-2,4-dienamide
Molecular Weight:
251.41
Molecular Formula:
C16H29NO
Solubility:
Soluble in DMSO (up to 25 mg/ml) on in Ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Blue Ice

Triptolide | Immunosuppressant

CAS:
38748-32-2
Catalog Number:
10-2631
Activity:
Immunsuppressant
Chemical Name:
(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
Alternate Names:
PG490
Molecular Weight:
360.40
Molecular Formula:
C20H24O6
Solubility:
Soluble in DMSO (up to 7 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Pirfenidone | Antifibrotic

CAS:
53179-13-8
Catalog Number:
10-2307
Activity:
Antifibrotic
Chemical Name:
5-Methyl-1-phenyl-2(1H)-pyridinone
Molecular Weight:
185.23
Molecular Formula:
C12H11NO
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

VEGF

Other

Meleagrin | Met inhibitor, anticancer activity

CAS:
71751-77-4
Catalog Number:
10-1599
Activity:
Met inhibitor, anticancer activity
Chemical Name:
(3E,7aR,12aS-7a-(1,1-Dimethyl-2-propen-1-yl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazol-5-ylmethylene)-12-methoxy-1H,5H-imidazol[1’,2’:1,2]pyrido[2,3-b]indole-2,5(3H)-dione
Molecular Weight:
433.46
Molecular Formula:
C23H23N5O4
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT