my account
  Loading... Please wait...


Sort by
  • Dynasore |  304448-55-3 | Structure | Supplier
    Dynasore (304448-55-3) is a noncompetitive inhibitor of dynamin GTPase activity and blocks dynamin-dependent endocytosis in cells, including neurons. It inhibits the GTPase activity of dynamin1, dynamin2, and Drp1...

  • EPAC 5376753 | EPAC inhibitor
    EPAC 5376753 is an allosteric inhibitor of Epac1, IC50= 4 μM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by Epac including cAMP-induced increase in migration of cardiac fibroblasts...

  • Mdivi | 338967-87-6 | Structure | Supplier
    Mdivi (338967-87-6) is a selective inhibitor of Dnm1 GTPase (IC50=1-10 μM). Inhibits mitochondrial outer membrane permeabilization. Mdivi inhibits mitochondrial division and apoptosis. Cell permeable...

  • MLS-532223 | Structure | Supplier
    MLS-532223 is a high-affinity selective inhibitor of Rho family GTPases (EC50=10 μM). It inhibits EGF-stimulated Rac1 activation (3-10 μM). Cell permeable. References/Citations1) Surviladze et al. (2010),...

  • MLS-573151 | Structure | Supplier
    MLS-573151 is a potent and specific inhibitor of Cdc42 a small GTPase of the Rho-subfamily (IC50=2 μM). References/Citations1) Surviladze et al. (2010), Indentification of a small GTPase inhibitor using a high-throughput...

  • NSC-23766 | Rac1 GTPase inhibitor
    NSC-23766 (733767-34-5) is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely...

  • Salirasib | 162520-00-5 | Structure | Supplier
    Salirasib (162520-00-5) is a synthetic farnesylcysteine mimetic that inhibits ras proteins1,2 via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains3.  It has been...

Share Focus

Connect with Focus